Phenazone

Antipyrine
Systematic (IUPAC) name
1,2-dihydro- 1,5-dimethyl- 2-phenyl- 3H-pyrazol- 3-one
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 60-80-0 Y
ATC code N02BB01 S02DA03
PubChem CID 2206
DrugBank DB01435
ChemSpider 2121 Y
UNII T3CHA1B51H Y
KEGG D01776 Y
ChEBI CHEBI:31225 Y
ChEMBL CHEMBL277474 Y
Synonyms analgesine, antipyrine
Chemical data
Formula C11H12N2O 
Mol. mass 188.226 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Phenazone (INN), phenazon, antipyrine (USAN), or analgesine is an analgesic and antipyretic. It was first synthesized by Ludwig Knorr in 1883.[1] It is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 °C. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours. [2]

Adverse effects

Possible adverse effects include:

See also

References

  1. ^ Brune, K (1997). "The early history of non-opioid analgesics". Acute Pain 1: 33. doi:10.1016/S1366-0071(97)80033-2. 
  2. ^ http://www.mims.com/USA/drug/info/phenazone/?q=Other%20Ear%20Preparations&type=full