Hepatoprotection

Hepatoprotection or antihepatotoxicity is the ability to prevent damage to the liver.

An example of a hepatoprotective medicine is silibinin, derived from Milk Thistle, which selectively inhibits leukotriene formation by Kupffer cells.^[1]

Herbs with potentially hepatoprotective constituents

• Almond oil^[2]
• Amomum xanthoides^[3]
• Arctium lappa^[4]
• Astragalus membranaceus^[5]
• Cichorium intybus^[6]
• Curcuma longa
• Cajanus indicus,^[7][8]
• Centella asiatica^[9]
• Coccinia indica'^[10]
• Eclipta^[11]
• Flickingeria fimbriata ^[12]
• Ganoderma lucidum^[13]
• Glycyrrhiza glabra^[14]
• Halenia elliptica^[15] (a medicinal herb of Tibetan folk medicine used to treat hepatitis.)
• Kalopanax pictus^[16] ?
• Murraya koenigii
• Nymphaea stellata^[17]
• Ocimum sanctum
• Paeonia lactiflora
• Pergularia daemia^[18][19][20]
• Picrorhiza kurrooa
• Phyllanthus amarus^[21][22]
• Plumbago zeylanica^[23]
• Silybum marianum^[24]
• Scoparia dulcis ^[25]
• Salvia miltiorrhiza^[26][27]
• Scutellaria baicalensis
• Schisandra chinensis^[28]
• Terminalia catappa^[29][30]
• Tinospora cordifolia
• Zizyphus mauritiana^[31]
• Vitis thunbergii, V. flexuosa, and V. kelungensis - three common wild grapes from Taiwan^[32]
• Paeonia lactiflora and Astragalus membranaceus:- The extract from the roots of P. lactiflora and A. membranaceus demonstrated better hepatoprotective activity than the herbs used individually.^[33]
• Chinese traditional prescriptions:-. Simo Yin , Guizhi Fuling Wan, Xieqing Wan, and Sini San.^[34]
• Ayurvedic herbs (30)^[35]

See also

• Hepatotoxicity

References

1. ^ Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Dehmlow, Carola; Erhard, Jochen; De Groot, Herbert. Hepatology (1996), 23(4), 749-54.
2. ^ Jia X.-Y., Zhang Q.-A., Zhang Z.-Q., Wang Y., Yuan J.-F., Wang H.-Y., Zhao D."Hepatoprotective effects of almond oil against carbon tetrachloride induced liver injury in rats" Food Chemistry 2011 125:2 (673-678)
3. ^ Wang J.-H., Shin J.-W., Kim H.-G., Hye-Jung P., Choi M.K., Son C.-G."Hepatoprotective and antioxidant effects of ethyl acetate soluble fraction of Amomum xanthoides Hepatology International 2010 4:1 (281-282)
4. ^ Lin S.C., Lin C.H., Lin C.C., Lin Y.H., Chen C.F., Chen I.C., Wang L.Y. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. Journal of biomedical science 2002 9:5 (401-409)
5. ^ Chien C.-F., Wu Y.-T., Tsai T.-H."Biological analysis of herbal medicines used for the treatment of liver diseases" Biomedical Chromatography 2011 25:1 (21-38)
6. ^ Tabassum N., Qazi M.A., Shah A., Shah M.Y. Curative potential of Kashni (Cichorium intybus Linn.) extract against carbon tetrachloride induced hepatocellular damage in rats Pharmacologyonline 2010 2 (971-978)
7. ^ Sarkar K., Sil P.C. Attenuation of acetaminophen-induced hepatotoxicity in vivo and in vitro by a 43-kD protein isolated from the herb Cajanus indicus L Toxicology Mechanisms and Methods 2007 17:6 (305-315
8. ^ Manna P., Sinha M., Sil P.C. A 43 kD protein isolated from the herb Cajanus indicus L attenuates sodium fluoride-induced hepatic and renal disorders in vivo Journal of Biochemistry and Molecular Biology 2007 40:3 (382-395)
9. ^ Haleagrahara N., Chakravarthi S., Kumar P. A study of protective effect of centella asiatica in 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced liver injury Haleagrahara N., Chakravarthi S., Kumar P. Hepatology International 2009 3:1 (196-197)
10. ^ Rao G.M.M., Vijayakumar M., Rao Ch.V., Rawat A.K.S., Mehrotra S. Hepatoprotective effect of Coccinia indica against CCl4 induced hepatotoxicity Natural Product Sciences 2003 9:1 (13-17)
11. ^ Xu R.-M., Deng K.-M., Lu Y.,"Studies on strengthening and restoring effects and hepatoprotective effect of Eclipta" Journal of Shanghai Jiaotong University (Medical Science) 2009 29:10 (1200-1204
12. ^ Datta G.K., Chakrabartya M., Ghosh S., Debnath P.K. Hepatoprotective effect of Desmotrichum fimbriatum Bl. in mice with carbon tetrachloride-induced liver damage' Biomedical Research 2002 13:2-3 (81-84)
13. ^ Wang X., Zhao X., Li D., Lou Y.-Q., Lin Z.-B., Zhang G.-L.Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-Immune hepatic injury in rats Biological and Pharmaceutical Bulletin 2007 30:9 (1702-1706
14. ^ Choi H.-J., Lee W.-J., Park S.-H., Song B.-W., Kim D.-H., Kim N.-J. Studies on the processing of crude drugs(IX) - Preparing standardization and regulation of stir-frying Glycyrrhzia root(1) Korean Journal of Pharmacognosy 2005 36:3 (209-219
15. ^ Huang B., Ban X., He J., Zeng H., Zhang P., Wang Y. Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica Journal of Ethnopharmacology 2010 131:2 (276-281)
16. ^ Hyun T.K., Kim J.-S."The pharmacology and clinical properties of Kalopanax pictus" Journal of Medicinal Plant Research 2009 3:9 (613-620)
17. ^ Soni N., Ahmed B., Upadhyay R."Nymphasterol, a new steroid from nymphaea stellata Verma A.", Medicinal Chemistry Research 2010 19 SUPPL. 1 (S47-S48)
18. ^ In-vitro evaluation of hepatoprotecttve activity of Pergularia daemia Forsk Sureshkumar S.V., Mishra S.H. Pharmacognosy Magazine 2008 4:16 (298-302)
19. ^ Karthishwaran K., Mirunalini S."Therapeutic potential of Pergularia daemia (Forsk.): The ayurvedic wonder" International Journal of Pharmacology 2010 6:6 (836-843)
20. ^ Sureshkumar S.V., Mishra S.H. Hepatoprotective activity of extracts from Pergularia daemia Forsk. against carbon tetrachloride-induced toxicity in rats Pharmacognosy Magazine 2007 3:11 (187-191)
21. ^ Naaz F., Javed S., Abdin M.Z. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice Journal of Ethnopharmacology 2007 113:3 (503-509)
22. ^ Chatterjee M., Sil P.C. Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian journal of biochemistry & biophysics 2006 43:5 (299-305)
23. ^ Kumar R., Kumar S., Patra A., Jayalakshmi S. Hepatoprotective activity of aerial parts of Plumbago zeylanica linn against carbon tetrachloride-induced hepatotoxicity in rats International Journal of Pharmacy and Pharmaceutical Sciences 2009 1:SUPPL. 1 (171-175)
24. ^ Bedi S., Goel A., Chand N., Rai J. A prospective study for evaluating the effect of Silymarin on hepatic functions in tubercular patients receiving DOTS Chest 2009 136:4
25. ^ Hepatoprotective evaluation of Scoparia dulcis L. Sahoo A.K., Madhavan V. Journal of Complementary and Integrative Medicine 2009 6:1 Article Number 37
26. ^ Song Y.-H., Liu Q., Lv Z.-P., Chen Y.-Y., Zhou Y.-C., Sun X.-G. Protection of a polysaccharide from Salvia miltiorrhiza, a Chinese medicinal herb, against immunological liver injury in mice International Journal of Biological Macromolecules 2008 43:2 (170-175)
27. ^ Lin Y.-L., Wu C.-H., Luo M.-H., Huang Y.-J., Wang C.-N., Shiao M.-S., Huang Y.-T. In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells Journal of Ethnopharmacology 2006 105:1-2 (215-222)
28. ^ Yip A.Y.S., Loo W.T.Y., Chow L.W.C. Fructus Schisandrae (Wuweizi) containing compound in modulating human lymphatic system - a Phase I minimization clinical trial Biomedicine and Pharmacotherapy 2007 61:9 SPEC. ISS. (588-590)
29. ^ Kinoshita S., Inoue Y., Nakama S., Ichiba T., Aniya Y. Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin Phytomedicine 2007 14:11 (755-762)
30. ^ Subasini U., Rajamanickam G.V., Dubey G.P., Prabu P.C., Savariraj Sahayam C., Mohammed Shabi M., Gayathri K., Agrawal A. Hydroalcoholic extract of Terminalia arjuna: A potential hepatoprotective herb Journal of Biological Sciences 2007 7:2 (255-262)
31. ^ Adhvaryu M.R., Reddy N., Parabia M.H. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs World Journal of Gastroenterology 2007 13:23 (3199-3205)
32. ^ Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice Huang C.-C., Tung Y.-T., Cheng K.-C., Wu J.-H. Food Chemistry 2011 125:2 (726-731)
33. ^ Sun W.-Y., Wei W., Gui S.-Y., Wu L., Wang H. Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by Bacillus Calmette-Guérin and lipopolysaccharide in mice Basic and Clinical Pharmacology and Toxicology 2008 103:2 (143-149)
34. ^ Lin K., Chen J., Tsauer W., Lin C., Lin J., Tsai C.-C. Prophylactic effect of four prescriptions of traditional Chinese medicine on α-naphthylisothiocyanate and carbon tetrachloride induced toxicity in rats Acta Pharmacologica Sinica 2001 22:12 (1159-1167)
35. ^ Martha B.R. "Overview of certain Ayurvedic herbs in the management of hepatitis B: A clinical study" Hepatology Research 2010 40:7 (750)