Anti-IL-6

Anti-interleukin-6 agents are a recent class of therapeutics.

Interleukin-6 is relevant to many inflammatory diseases and many cancers. Hence anti-IL-6 agents have been sought. [1] [2] [3] [4] [5]

The first approved, tocilizumab (Actemra), actually acts against the IL-6 receptor.

In clinical trials : Elsilimomab for some cancers, Anti-IL-6 chimeric monoclonal antibody (CNTO 328), ALD518, CNTO 136, CPSI-2364[6], CDP6038[7].

Pre-clinical : VX30 for rheumatoid arthritis[8]. Also ARGX-109[9], FE301[10], FM101[11]

Food/diet

It has been reported that lunasin, a soy peptide, reduces inflammation by reducing interleukin-6 and may help in leukemia[12].

Luteolin reduces IL-6 production in some neurons.[13]

References

  1. ^ Barton BE (August 2005). "Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes". Expert Opin. Ther. Targets 9 (4): 737–52. doi:10.1517/14728222.9.4.737. PMID 16083340. 
  2. ^ Smolen JS, Maini RN (2006). "Interleukin-6: a new therapeutic target". Arthritis Res. Ther. 8 Suppl 2: S5. doi:10.1186/ar1969. PMID 16899109. 
  3. ^ Stein and Sutherland (1998). "IL-6 as a drug discovery target". Drug Discovery Today 3 (5): 202–213. doi:10.1016/S1359-6446(97)01164-1. 
  4. ^ "Interleukin-6 - new target in the battle against Ras-induced cancers". 2007. http://www.news-medical.net/news/2007/07/16/27599.aspx. 
  5. ^ Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis. 2003. http://journals.lww.com/co-rheumatology/Abstract/2003/09000/Interleukin_6_as_a_therapeutic_target_in.10.aspx. 
  6. ^ "CPSI-2364". http://www.cytokinepharmasciences.com/CPSI-2364.shtml. 
  7. ^ "UCB Announces Start Of Phase I Study For Antibody Drug Candidate CDP6038". 2 Dec 2008. http://www.medicalnewstoday.com/articles/131407.php. 
  8. ^ http://www.vaccinex.com/pipeline-antibody-vx30-autoimmune-disease.htm Good summary of IL-6
  9. ^ "ArGEN-X Wins €1.5M IWT Grant to Progress Camelid-Derived Human Antibody Pipeline". 27 Sep 2010. http://www.genengnews.com/gen-news-highlights/argen-x-wins-1-5m-iwt-grant-to-progress-camelid-derived-human-antibody-pipeline/81243979/. 
  10. ^ "Ferring and Conaris complete license agreement for new recombinant molecule in gastroenterology". 10 Dec 2008. http://www.conaris.de/081210__Press_release_Conaris_Ferring__EN.pdf. 
  11. ^ "Formatech to Donate Services to Formulate and Fill Femta Pharmaceuticals’ FM101 Monoclonal Antibody under Its “Fillanthrop". 30 July 2010. http://www.fiercebiotech.com/press-releases/formatech-donate-services-formulate-and-fill-femta-pharmaceuticals-fm101-monoclonal-a. 
  12. ^ http://www.foodconsumer.org/newsite/Nutrition/Supplements/soy_protein_helps_fight_cancer_and_inflammation_021220090906.html
  13. ^ Johnson et al.; Kelley, KW; Johnson, RW (May 2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 — PNAS". Proceedings of the National Academy of Sciences of the United States of America 105 (21): 7534–9. doi:10.1073/pnas.0802865105. PMC 2396685. PMID 18490655. http://www.pnas.org/cgi/content/abstract/105/21/7534?lookupType=volpage&vol=105&fp=7534&view=short.