Alpha-aminoadipate pathway

The α-aminoadipate pathway is a biochemical pathway for the synthesis of the amino acid L-lysine. In the eukaryotes, this pathway is unique to the higher fungi (containing chitin in their cell walls) and the euglenids.[1] It has also been reported from bacteria of the genus Thermus.[2] The precursor compound for L-lysine is α-ketoglutarate; the seven enzymes involved are, sequentially: homocitrate synthase, homoaconitase, homoisocitrate dehydrogenase; α-aminoadipate aminotransferase; α-aminoadipate reductase, saccharopine reductase, and saccharopine dehydrogenase.[3]

References

  1. ^ Zabriskie TM, Jackson MD. (2000). "Lysine biosynthesis and metabolism in fungi". Natural Product Reports 17 (1): 85–97. doi:10.1039/a801345d. PMID 10714900. 
  2. ^ Kosuge T, Hoshino T (1999). "The α-aminoadipate pathway for lysine biosynthesis is widely distributed among Thermus strains". Journal of Bioscience and Bioengineering 88 (6): 672–5. doi:10.1016/S1389-1723(00)87099-1. PMID 16232683. 
  3. ^ Xu H, Andi B, Qian J, West AH, Cook PF (2006). "The α-aminoadipate pathway for lysine biosynthesis in fungi". Cell Biochemistry and Biophysics 46 (1): 43–64. doi:10.1385/CBB:46:1:43. PMID 16943623.