Aleglitazar

Aleglitazar

IUPAC name (2S)-2-methoxy-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]- 7-benzothiophenyl]propanoic acid
Other names Ro-0728804, R-1439
Identifiers
CAS number	475479-34-6
PubChem	10274777
ChemSpider	8450255^Y
DrugBank	DB08483
KEGG	D08845^Y
ChEMBL	CHEMBL519504^Y
Jmol-3D images	Image 1 Image 2
SMILES CC1=C(CCOc2ccc(C[C@H](OC)C(O[H])=O)c3c2C=CS3)N=C(c4ccccc4)O1 O=C(O)[C@@H](OC)Cc4ccc(OCCc1nc(oc1C)c2ccccc2)c3c4scc3
InChI InChI=1S/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1^Y Key: DAYKLWSKQJBGCS-NRFANRHFSA-N^Y InChI=1/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1 Key: DAYKLWSKQJBGCS-NRFANRHFBF
Properties
Molecular formula	C₂₄H₂₃NO₅S
Molar mass	437.50812
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Aleglitazar is a peroxisome proliferator-activated receptor agonist (hence a PPAR modulator ) with affinity to PPARα and PPARγ, which is being developed by Hoffmann–La Roche for the treatment of type II diabetes.^[1] It is currently in phase II clinical trials.^[2]

References

Biguanides	Metformin^# • Buformin^‡ • Phenformin^‡

TZDs (PPAR)	Pioglitazone • Rivoglitazone^† • Rosiglitazone • Troglitazone^‡

Dual PPAR agonist	Aleglitazar^† • Muraglitazar^§ • Tesaglitazar^§

Sulfonylureas	1st generation: Acetohexamide • Carbutamide • Chlorpropamide • Tolbutamide • Tolazamide 2nd generation: Glibenclamide (Glyburide)^# • Glipizide • Gliquidone • Glyclopyramide • Glimepiride • Gliclazide •

Meglitinides/"glinides"	Nateglinide • Repaglinide • Mitiglinide

Analogs/other insulins

fast-acting (Insulin lispro • Insulin aspart • Insulin glulisine) • short-acting (Regular insulin) • long-acting (Insulin glargine • Insulin detemir • NPH insulin) • ultra-long-acting (Insulin degludec^†) • inhalable Exubera^‡

Other

Alpha-glucosidase inhibitors	Acarbose • Miglitol • Voglibose

Amylin analog	Pramlintide

SGLT2 inhibitors	Canagliflozin^† • Dapagliflozin^† • Remogliflozin^§ • Sergliflozin^§

Other	Benfluorex^‡ • Tolrestat^‡

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)