Afloqualone

Afloqualone
Systematic (IUPAC) name
6-amino- 2-(fluoromethyl)- 3-(2-methylphenyl) quinazolin- 4-one
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 56287-74-2
ATC code None
PubChem CID 2040
ChemSpider 1960 Y
UNII CO4U2C8ORZ Y
KEGG D01638 Y
Chemical data
Formula C16H14FN3O 
Mol. mass 283.3
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Afloqualone (Arofuto) is an analogue of methaqualone developed in the 1980s in Japan. It has sedative and muscle relaxant effects,[1] and has had some clinical use, although it causes photosensitization as a side effect which can cause skin problems such as dermatitis.[2]

See also

References

  1. ^ Ochiai T, Ishida R. Pharmacological studies on 6-amino- 2-fluoromethyl- 3-(O-tolyl)- 4(3H)- quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Japanese Journal of Pharmacology. 1982 Jun;32(3):427-38.
  2. ^ Ishikawa T, Kamide R, Niimura M. Photoleukomelanodermatitis (Kobori) induced by afloqualone. Journal of Dermatology. 1994 Jun;21(6):430-3.