| Aerolysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| proaerolysin | |||||||||
| Identifiers | |||||||||
| Symbol | Aerolysin | ||||||||
| Pfam | PF01117 | ||||||||
| Pfam clan | CL0345 | ||||||||
| InterPro | IPR005830 | ||||||||
| PROSITE | PDOC00247 | ||||||||
| SCOP | 1pre | ||||||||
| TCDB | 1.C.4 | ||||||||
|
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In molecular biology, aerolysin is a cytolytic toxin exported by Aeromonas hydrophila, a Gram-negative bacterium associated with diarrhoeal diseases and deep wound infections.[1][2] The mature toxin binds to eukaryotic cells and aggregates to form holes (approximately 3 nm in diameter) leading to the destruction of the membrane permeability barrier and osmotic lysis. The structure of proaerolysin has been determined to 2.8A resolution and shows the protoxin to adopt a novel fold.[2] Images of an aerolysin oligomer derived from electron microscopy have helped to construct a model of the protein and to outline a mechanism by which it might insert into lipid bilayers to form ion channels.[2]
This article incorporates text from the public domain Pfam and InterPro IPR005830