Acenocoumarol

Acenocoumarol
Systematic (IUPAC) name
(RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. X
Legal status POM (UK)
Routes Oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 8 to 11 hours
Identifiers
CAS number 152-72-7 Y
ATC code B01AA07
PubChem CID 9052
DrugBank DB01418
ChemSpider 10443441 Y
UNII I6WP63U32H Y
KEGG D07064 Y
ChEBI CHEBI:53766 Y
ChEMBL CHEMBL397420 Y
Chemical data
Formula C19H15NO6 
Mol. mass 353.326 g·mol-1
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.

Dosage

Research in the RECAVA network has discovered that two acquired factors (age and body mass index) and three genetic polymorphisms (genes VKORC1, CYP2C9 and CYP4F2) are useful to establish the right dosage. Acenocoumarol is contraindicated during pregnancy.

External links