Abarelix

Abarelix

Systematic (IUPAC) name
acetyl-D-β-naphthylalanyl- D-4-chlorophenylalanyl-D-3-pyridylalanyl-L-seryl-L- N-methyl- tyrosyl-D-asparagyl-L-leucyl-L-N(e )-isopropyl-lysyl-L-prolyl-D-alanyl-amide
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	96–99%
Identifiers
CAS number	183552-38-7^N
ATC code	L02BX01
PubChem	CID 16131215
IUPHAR ligand	1188
DrugBank	BTD00051
ChemSpider	10482301^Y
UNII	W486SJ5824^Y
KEGG	D02738^Y
ChEBI	CHEBI:337298^Y
ChEMBL	CHEMBL1252^Y
Chemical data
Formula	C₇₂H₉₅Cl N₁₄O₁₄
Mol. mass	1416.06 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C72H95ClN14O14/c1-41(2)32-54(64(93)80-53(17-10-11-30-77-42(3)4)72(101)87-31-13-18-60(87)69(98)78-43(5)63(75)92)81-68(97)58(38-62(74)91)84-70(99)61(37-46-22-27-52(90)28-23-46)86(7)71(100)59(40-88)85-67(96)57(36-48-14-12-29-76-39-48)83-66(95)56(34-45-20-25-51(73)26-21-45)82-65(94)55(79-44(6)89)35-47-19-24-49-15-8-9-16-50(49)33-47/h8-9,12,14-16,19-29,33,39,41-43,53-61,77,88,90H,10-11,13,17-18,30-32,34-38,40H2,1-7H3,(H2,74,91)(H2,75,92)(H,78,98)(H,79,89)(H,80,93)(H,81,97)(H,82,94)(H,83,95)(H,84,99)(H,85,96)/t43-,53+,54+,55-,56-,57-,58-,59+,60+,61+/m1/s1^Y Key:AIWRTTMUVOZGPW-HSPKUQOVSA-N^Y
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Abarelix is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in oncology to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. It belongs to the family of drugs called Gonadotropin-releasing hormone antagonists.

It is marketed by Speciality European Pharma as Plenaxis. Plenaxis has received marketing authorisation in Germany.

Agonist	Buserelin • Goserelin • Histrelin • Leuprorelin • Nafarelin • Triptorelin • Deslorelin

Antagonist	Abarelix • Cetrorelix • Degarelix • Ganirelix