AURKC
Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene.[1][2]
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.[2]
References
Further reading
- Katayama H, Brinkley WR, Sen S (2004). "The Aurora kinases: role in cell transformation and tumorigenesis.". Cancer Metastasis Rev. 22 (4): 451–64. doi:10.1023/A:1023789416385. PMID 12884918.
- Tseng TC, Chen SH, Hsu YP, Tang TK (1998). "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators.". DNA Cell Biol. 17 (10): 823–33. doi:10.1089/dna.1998.17.823. PMID 9809744.
- Kimura M, Matsuda Y, Yoshioka T, Okano Y (1999). "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3.". J. Biol. Chem. 274 (11): 7334–40. doi:10.1074/jbc.274.11.7334. PMID 10066797.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Li X, Sakashita G, Matsuzaki H, et al. (2004). "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.". J. Biol. Chem. 279 (45): 47201–11. doi:10.1074/jbc.M403029200. PMID 15316025.
- Sasai K, Katayama H, Stenoien DL, et al. (2005). "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.". Cell Motil. Cytoskeleton 59 (4): 249–63. doi:10.1002/cm.20039. PMID 15499654.
- Yan X, Wu Y, Li Q, et al. (2005). "Cloning and characterization of a novel human Aurora C splicing variant.". Biochem. Biophys. Res. Commun. 328 (1): 353–61. doi:10.1016/j.bbrc.2004.12.168. PMID 15670791.
- Chen HL, Tang CJ, Chen CY, Tang TK (2005). "Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.". J. Biomed. Sci. 12 (2): 297–310. doi:10.1007/s11373-005-0980-0. PMID 15917996.
- Yan X, Cao L, Li Q, et al. (2005). "Aurora C is directly associated with Survivin and required for cytokinesis.". Genes Cells 10 (6): 617–26. doi:10.1111/j.1365-2443.2005.00863.x. PMID 15938719.
- Dutertre S, Hamard-Péron E, Cremet JY, et al. (2006). "The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression.". Cell Cycle 4 (12): 1783–7. PMID 16258285.
- Dieterich K, Soto Rifo R, Faure AK, et al. (2007). "Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.". Nat. Genet. 39 (5): 661–5. doi:10.1038/ng2027. PMID 17435757.