ATRN

For the ATRN Extended SMTP command, see On-Demand Mail Relay.

Attractin

Identifiers

ATRN; DPPT-L; KIAA0548; MGC126754; MGCA

External IDs

OMIM: 603130 MGI: 1341628 HomoloGene: 22542 GeneCards: ATRN Gene

Gene Ontology
Molecular function	• receptor activity • binding • sugar binding
Cellular component	• extracellular region • extracellular space • cytoplasm • plasma membrane • integral to plasma membrane
Biological process	• inflammatory response • response to oxidative stress • regulation of multicellular organism growth
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
3.45 – 3.63 Mb

Chr 2:
130.73 – 130.86 Mb

PubMed search

[1]

[2]

Attractin is a protein that in humans is encoded by the ATRN gene.^[1]^[2]^[3]

Attractin is a Group XI C-type lectin.

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.^[3]

References

^ Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF (Oct 1998). "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions". Proc Natl Acad Sci U S A 95 (19): 11336–41. doi:10.1073/pnas.95.19.11336. PMC 21643. PMID 9736737. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21643.
^ Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF (Apr 1996). "Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells". J Immunol 156 (5): 1714–21. PMID 8596018.
^ ^a ^b "Entrez Gene: ATRN attractin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8455.

Mori M, Sakurai M, Araie M (1993). "[Topical timolol and blood-aqueous barrier permeability to protein in human eyes]". Nippon Ganka Gakkai Zasshi 96 (11): 1418–22. PMID 1476071.
Nagase T, Ishikawa K, Miyajima N et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Nagle DL, McGrail SH, Vitale J et al. (1999). "The mahogany protein is a receptor involved in suppression of obesity". Nature 398 (6723): 148–52. doi:10.1038/18210. PMID 10086355.
Gunn TM, Miller KA, He L et al. (1999). "The mouse mahogany locus encodes a transmembrane form of human attractin". Nature 398 (6723): 152–6. doi:10.1038/18217. PMID 10086356.
Tang W, Gunn TM, McLaughlin DF et al. (2000). "Secreted and membrane attractin result from alternative splicing of the human ATRN gene". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6025–30. doi:10.1073/pnas.110139897. PMC 18552. PMID 10811918. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18552.
Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Friedrich D, Kühn-Wache K, Hoffmann T, Demuth HU (2003). "Isolation and characterization of attractin-2". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 524: 109–13. doi:10.1007/0-306-47920-6_14. ISBN 0-306-47717-3. PMID 12675230.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.
Wrenger S, Faust J, Friedrich D et al. (2007). "Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function". J. Leukoc. Biol. 80 (3): 621–9. doi:10.1189/jlb.1105678. PMID 16835316.

ATRN

References

Further reading