ATPAF1

ATP synthase mitochondrial F1 complex assembly factor 1

Identifiers

ATPAF1; ATP11; ATP11p; FLJ22351; FLJ60653; MGC88060

External IDs

OMIM: 608917 MGI: 2180560 HomoloGene: 41492 GeneCards: ATPAF1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• mitochondrion
Biological process	• protein complex assembly
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000123472

ENSMUSG00000028710

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
47.1 – 47.14 Mb

Chr 4:
115.46 – 115.49 Mb

PubMed search

ATP synthase mitochondrial F1 complex assembly factor 1, also known as ATP11 homolog, is a protein that in humans is encoded by the ATPAF1 gene.^[1]^[2]

Function

This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 beta subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. Alternatively spliced transcript variants have been identified, but the biological validity of some of these variants has not been determined.^[1]

References

^ ^a ^b "Entrez Gene: ATP synthase mitochondrial F1 complex assembly factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64756.
^ Wang ZG, White PS, Ackerman SH (August 2001). "Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria". J. Biol. Chem. 276 (33): 30773–8. doi:10.1074/jbc.M104133200. PMID 11410595.

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ackerman SH (2002). "Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria". Biochim. Biophys. Acta 1555 (1–3): 101–5. doi:10.1016/S0005-2728(02)00262-1. PMID 12206899.
Picková A, Paul J, Petruzzella V, Houstek J (2003). "Differential expression of ATPAF1 and ATPAF2 genes encoding F(1)-ATPase assembly proteins in mouse tissues". FEBS Lett. 551 (1–3): 42–6. doi:10.1016/S0014-5793(03)00890-1. PMID 12965202.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.