ATG12

ATG12 autophagy related 12 homolog (S. cerevisiae)
Identifiers
Symbols ATG12; APG12; APG12L; FBR93; HAPG12
External IDs OMIM609608 MGI1914776 HomoloGene37953 GeneCards: ATG12 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9140 67526
Ensembl ENSG00000145782 ENSMUSG00000032905
UniProt O94817 Q9CQY1
RefSeq (mRNA) NM_004707.3 NM_026217.3
RefSeq (protein) NP_004698 NP_080493.2
Location (UCSC) Chr 5:
115.16 – 115.18 Mb
Chr 18:
46.89 – 46.9 Mb
PubMed search [1] [2]

Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene.[1][2]

Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998).[supplied by OMIM][2]

References

  1. ^ Mizushima N, Sugita H, Yoshimori T, Ohsumi Y (Jan 1999). "A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy". J Biol Chem 273 (51): 33889–33892. doi:10.1074/jbc.273.51.33889. PMID 9852036. 
  2. ^ a b "Entrez Gene: ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9140. 

Further reading