Asporin
Asporin is a protein that in humans is encoded by the ASPN gene.[1]
ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).[supplied by OMIM][1]
References
Further reading
- Lorenzo P, Aspberg A, Onnerfjord P et al. (2001). "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". J. Biol. Chem. 276 (15): 12201–11. doi:10.1074/jbc.M010932200. PMID 11152692.
- Henry SP, Takanosu M, Boyd TC et al. (2001). "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family". J. Biol. Chem. 276 (15): 12212–21. doi:10.1074/jbc.M011290200. PMID 11152695.
- Yamada S, Murakami S, Matoba R et al. (2001). "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene 275 (2): 279–86. doi:10.1016/S0378-1119(01)00683-7. PMID 11587855.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kizawa H, Kou I, Iida A et al. (2005). "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis". Nat. Genet. 37 (2): 138–44. doi:10.1038/ng1496. PMID 15640800.
- Rodriguez-Lopez J, Pombo-Suarez M, Liz M et al. (2006). "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians". Arthritis Res. Ther. 8 (3): R55. doi:10.1186/ar1920. PMC 1526645. PMID 16542493. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1526645.
- Yamada S, Ozawa Y, Tomoeda M et al. (2006). "Regulation of PLAP-1 expression in periodontal ligament cells". J. Dent. Res. 85 (5): 447–51. doi:10.1177/154405910608500510. PMID 16632759.
- Jiang Q, Shi D, Yi L et al. (2007). "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese". J. Hum. Genet. 51 (12): 1068–72. doi:10.1007/s10038-006-0065-6. PMID 17024313.
- Nakamura T, Shi D, Tzetis M et al. (2007). "Meta-analysis of association between the ASPN D-repeat and osteoarthritis". Hum. Mol. Genet. 16 (14): 1676–81. doi:10.1093/hmg/ddm115. PMID 17517696.
- Shi D, Nakamura T, Dai J et al. (2007). "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population". J. Hum. Genet. 52 (8): 664–7. doi:10.1007/s10038-007-0166-x. PMID 17603749.
- Kou I, Nakajima M, Ikegawa S (2007). "Expression and regulation of the osteoarthritis-associated protein asporin". J. Biol. Chem. 282 (44): 32193–9. doi:10.1074/jbc.M706262200. PMID 17804408.
- Nakajima M, Kizawa H, Saitoh M et al. (2007). "Mechanisms for asporin function and regulation in articular cartilage". J. Biol. Chem. 282 (44): 32185–92. doi:10.1074/jbc.M700522200. PMID 17827158.