ARHGEF11
Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.[1][2][3]
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.[3]
Interactions
ARHGEF11 has been shown to interact with PLXNB3,[4][5] PLXNB1,[4][6][5][7] PLXNB2[4][5] and RHOA.[1]
References
- ^ a b Rumenapp U, Blomquist A, Schworer G, Schablowski H, Psoma A, Jakobs KH (Nov 1999). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Lett 459 (3): 313–8. doi:10.1016/S0014-5793(99)01270-3. PMID 10526156.
- ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
- ^ a b "Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9826.
- ^ a b c Perrot, Valerie; Vazquez-Prado Jose, Gutkind J Silvio (Nov. 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. (United States) 277 (45): 43115–20. doi:10.1074/jbc.M206005200. ISSN 0021-9258. PMID 12183458.
- ^ a b c Swiercz, Jakub M; Kuner Rohini, Behrens Jürgen, Offermanns Stefan (Jul. 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron (United States) 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. ISSN 0896-6273. PMID 12123608.
- ^ Oinuma, Izumi; Katoh Hironori, Harada Amane, Negishi Manabu (Jul. 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. (United States) 278 (28): 25671–7. doi:10.1074/jbc.M303047200. ISSN 0021-9258. PMID 12730235.
- ^ Hirotani, Mutsumi; Ohoka Yoshiharu, Yamamoto Takahiro, Nirasawa Hiromi, Furuyama Tatsuo, Kogo Mikihiko, Matsuya Tokuzo, Inagaki Shinobu (Sep. 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. (United States) 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. ISSN 0006-291X. PMID 12220504.
Further reading
- Fukuhara S, Murga C, Zohar M, et al. (1999). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". J. Biol. Chem. 274 (9): 5868–79. doi:10.1074/jbc.274.9.5868. PMID 10026210.
- Togashi H, Nagata K, Takagishi M, et al. (2000). "Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization". J. Biol. Chem. 275 (38): 29570–8. doi:10.1074/jbc.M003726200. PMID 10900204.
- Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047.
- Longenecker KL, Lewis ME, Chikumi H, et al. (2001). "Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases". Structure 9 (7): 559–69. doi:10.1016/S0969-2126(01)00620-7. PMID 11470431.
- Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
- Driessens MH, Olivo C, Nagata K, et al. (2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Lett. 529 (2–3): 168–72. doi:10.1016/S0014-5793(02)03323-9. PMID 12372594.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Barac A, Basile J, Vázquez-Prado J, et al. (2004). "Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor". J. Biol. Chem. 279 (7): 6182–9. doi:10.1074/jbc.M309579200. PMID 14625312.
- Davidkova G, McCullumsmith RE, Meador-Woodruff JH (2004). "Expression of ARHGEF11 mRNA in schizophrenic thalamus". Ann. N. Y. Acad. Sci. 1003: 375–7. doi:10.1196/annals.1300.030. PMID 14684465.
- Banerjee J, Wedegaertner PB (2004). "Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton". Mol. Biol. Cell 15 (4): 1760–75. doi:10.1091/mbc.E03-07-0527. PMC 379273. PMID 14742719. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=379273.
- Wang Q, Liu M, Kozasa T, et al. (2004). "Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells". J. Biol. Chem. 279 (28): 28831–4. doi:10.1074/jbc.C400105200. PMID 15143072.
- Guo X, Li Y, Peng K, et al. (2006). "Solution structures and backbone dynamics of arsenate reductase from Bacillus subtilis: reversible conformational switch associated with arsenate reduction". J. Biol. Chem. 280 (47): 39601–8. doi:10.1074/jbc.M508132200. PMID 16192272.
- Longhurst DM, Watanabe M, Rothstein JD, Jackson M (2006). "Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity". J. Biol. Chem. 281 (17): 12030–40. doi:10.1074/jbc.M513756200. PMID 16478718.
- Gu J, Wu X, Dong Q, et al. (2006). "A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans". Cancer 106 (12): 2716–24. doi:10.1002/cncr.21944. PMID 16691626.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ma L, Hanson RL, Que LN, et al. (2007). "Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians". Diabetes 56 (5): 1454–9. doi:10.2337/db06-0640. PMID 17287471.
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PDB gallery
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1htj: STRUCTURE OF THE RGS-LIKE DOMAIN FROM PDZ-RHOGEF
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1xcg: Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF
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2dls: Solution structure of the PDZ domain of human Rho guanine nucleotide exchange factor 11
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