ARHGDIG

Rho GDP dissociation inhibitor (GDI) gamma

Identifiers

External IDs

OMIM: 602844 MGI: 108430 HomoloGene: 7337 GeneCards: ARHGDIG Gene

Gene Ontology
Molecular function	• Rho GDP-dissociation inhibitor activity • GTPase activator activity
Cellular component	• membrane fraction • cytoplasm • cytosol • cytoplasmic membrane-bounded vesicle
Biological process	• negative regulation of cell adhesion • small GTPase mediated signal transduction • Rho protein signal transduction • regulation of protein localization • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
0.32 – 0.33 Mb

Chr 17:
26.34 – 26.34 Mb

PubMed search

[1]

[2]

Rho GDP-dissociation inhibitor 3 is a protein that in humans is encoded by the ARHGDIG gene.^[1]^[2]^[3]

Interactions

ARHGDIG has been shown to interact with RHOB.^[4]

References

^ Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B (May 1997). "RhoGDIγ: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas". Proc Natl Acad Sci U S A 94 (9): 4279–84. doi:10.1073/pnas.94.9.4279. PMC 20713. PMID 9113980. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20713.
^ Brunet N, Morin A, Olofsson B (Apr 2002). "RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain". Traffic 3 (5): 342–57. doi:10.1034/j.1600-0854.2002.30504.x. PMID 11967128.
^ "Entrez Gene: ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=398.
^ Zalcman, G; Closson V, Camonis J, Honoré N, Rousseau-Merck M F, Tavitian A, Olofsson B (Nov. 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. (UNITED STATES) 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. ISSN 0021-9258. PMID 8939998.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zalcman G, Closson V, Camonis J et al. (1997). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. PMID 8939998.
Adra CN, Iyengar AR, Syed FA et al. (1998). "Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3". Genomics 53 (1): 104–9. doi:10.1006/geno.1998.5482. PMID 9787082.
Elenich LA, Nandi D, Kent AE et al. (1999). "The complete primary structure of mouse 20S proteasomes". Immunogenetics 49 (10): 835–42. doi:10.1007/s002510050562. PMID 10436176.
Daniels RJ, Peden JF, Lloyd C et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Li X, Bu X, Lu B et al. (2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol. 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. PMC 134637. PMID 11809807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134637.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
del Pozo MA, Alderson NB, Kiosses WB et al. (2004). "Integrins regulate Rac targeting by internalization of membrane domains". Science 303 (5659): 839–42. doi:10.1126/science.1092571. PMID 14764880.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Dransart E, Morin A, Cherfils J, Olofsson B (2005). "Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors". J. Biol. Chem. 280 (6): 4674–83. doi:10.1074/jbc.M409741200. PMID 15513926.
Martin J, Han C, Gordon LA et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.

ARHGDIG

Interactions

References

Further reading