ARHGDIB

Rho GDP dissociation inhibitor (GDI) beta

PDB rendering based on 1ds6.

Available structures
PDB	1ds6

Identifiers

Symbols

ARHGDIB; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2

External IDs

OMIM: 602843 MGI: 101940 HomoloGene: 20318 GeneCards: ARHGDIB Gene

Gene Ontology
Molecular function	• Rho GDP-dissociation inhibitor activity • GTPase activator activity
Cellular component	• cytoplasm • cytosol • cytoskeleton • cytoplasmic membrane-bounded vesicle
Biological process	• cellular component movement • immune response • negative regulation of cell adhesion • small GTPase mediated signal transduction • Rho protein signal transduction • multicellular organismal development • actin cytoskeleton organization • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
15.09 – 15.11 Mb

Chr 6:
136.87 – 136.89 Mb

PubMed search

[1]

[2]

Rho GDP-dissociation inhibitor 2 is a protein that in humans is encoded by the ARHGDIB gene.^[1]^[2]^[3]

Interactions

ARHGDIB has been shown to interact with VAV1.^[4]

References

^ Lelias JM, Adra CN, Wulf GM, Guillemot JC, Khagad M, Caput D, Lim B (Mar 1993). "cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins". Proc Natl Acad Sci U S A 90 (4): 1479–83. doi:10.1073/pnas.90.4.1479. PMC 45897. PMID 8434008. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=45897.
^ Scherle P, Behrens T, Staudt LM (Sep 1993). "Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes". Proc Natl Acad Sci U S A 90 (16): 7568–72. doi:10.1073/pnas.90.16.7568. PMC 47183. PMID 8356058. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47183.
^ "Entrez Gene: ARHGDIB Rho GDP dissociation inhibitor (GDI) beta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=397.
^ Groysman, M; Russek C S, Katzav S (Feb. 2000). "Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation". FEBS Lett. (NETHERLANDS) 467 (1): 75–80. doi:10.1016/S0014-5793(00)01121-2. ISSN 0014-5793. PMID 10664460.

Aebersold R, Leavitt J (1990). "Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database.". Electrophoresis 11 (7): 517–27. doi:10.1002/elps.1150110702. PMID 2226408.
Shisheva A, Südhof TC, Czech MP (1994). "Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.". Mol. Cell. Biol. 14 (5): 3459–68. PMC 358710. PMID 7513052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=358710.
Adra CN, Kobayashi H, Rowley JD, Lim B (1995). "Assignment of the human GDID4 gene, a GDP/GTP-exchange regulator, to chromosome 12p12.3.". Genomics 24 (1): 188–90. doi:10.1006/geno.1994.1601. PMID 7896279.
Leffers H, Nielsen MS, Andersen AH, et al. (1994). "Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.". Exp. Cell Res. 209 (2): 165–74. doi:10.1006/excr.1993.1298. PMID 8262133.
Adra CN, Manor D, Ko JL, et al. (1997). "RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4279–84. doi:10.1073/pnas.94.9.4279. PMC 20713. PMID 9113980. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20713.
Takahashi K, Sasaki T, Mammoto A, et al. (1997). "Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein.". J. Biol. Chem. 272 (37): 23371–5. doi:10.1074/jbc.272.37.23371. PMID 9287351.
Gorvel JP, Chang TC, Boretto J, et al. (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.". FEBS Lett. 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022.
Illenberger D, Schwald F, Pimmer D, et al. (1999). "Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.". EMBO J. 17 (21): 6241–9. doi:10.1093/emboj/17.21.6241. PMC 1170950. PMID 9799233. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170950.
Scheffzek K, Stephan I, Jensen ON, et al. (2000). "The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.". Nat. Struct. Biol. 7 (2): 122–6. doi:10.1038/72392. PMID 10655614.
Groysman M, Russek CS, Katzav S (2000). "Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation.". FEBS Lett. 467 (1): 75–80. doi:10.1016/S0014-5793(00)01121-2. PMID 10664460.
Kasper B, Tidow N, Grothues D, Welte K (2000). "Differential expression and regulation of GTPases (RhoA and Rac2) and GDIs (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia.". Blood 95 (9): 2947–53. PMID 10779444.
Fauré J, Dagher MC (2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI).". Biochimie 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848.
Li X, Bu X, Lu B, et al. (2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.". Mol. Cell. Biol. 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. PMC 134637. PMID 11809807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134637.
Kwon KB, Park EK, Ryu DG, Park BH (2003). "D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells.". Exp. Mol. Med. 34 (1): 32–7. PMID 11989976.
Thiede B, Siejak F, Dimmler C, Rudel T (2003). "Prediction of translocation and cleavage of heterogeneous ribonuclear proteins and Rho guanine nucleotide dissociation inhibitor 2 during apoptosis by subcellular proteome analysis.". Proteomics 2 (8): 996–1006. doi:10.1002/1615-9861(200208)2:8<996::AID-PROT996>3.0.CO;2-3. PMID 12203895.
Groysman M, Hornstein I, Alcover A, Katzav S (2003). "Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways.". J. Biol. Chem. 277 (51): 50121–30. doi:10.1074/jbc.M204299200. PMID 12386169.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

PDB gallery

1ds6: CRYSTAL STRUCTURE OF A RAC-RHOGDI COMPLEX

ARHGDIB

Interactions

References

Further reading