ARHGAP8

Rho GTPase activating protein 8

Identifiers

ARHGAP8; BPGAP1; FLJ20185; PP610

External IDs

OMIM: 609405 MGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8 Gene

Gene Ontology
Molecular function	• GTPase activator activity • Rho GTPase activator activity • protein binding
Cellular component	• intracellular • cytosol
Biological process	• signal transduction • small GTPase mediated signal transduction • positive regulation of Rho GTPase activity • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction • positive regulation of ERK1 and ERK2 cascade
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

n/a

Chr 15:
84.55 – 84.6 Mb

PubMed search

[1]

[2]

Rho GTPase-activating protein 8 is an enzyme that in humans is encoded by the ARHGAP8 gene.^[1]^[2]

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.^[2]

References

^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–495. doi:10.1038/990031. PMID 10591208.
^ ^a ^b "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23779.

Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Shan Z, Haaf T, Popescu NC (2003). "Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8". Gene 303: 55–61. doi:10.1016/S0378-1119(02)01143-5. PMID 12559566.
Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–45914. doi:10.1074/jbc.M304514200. PMID 12944407.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration". Mol. Biol. Cell 15 (6): 2873–2883. doi:10.1091/mbc.E04-02-0141. PMC 420110. PMID 15064355. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=420110.
Johnstone CN, Castellví-Bel S, Chang LM et al. (2004). "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers". Gene 336 (1): 59–71. doi:10.1016/j.gene.2004.01.025. PMID 15225876.
Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID 15506981.
Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell. Sci. 118 (Pt 12): 2707–2721. doi:10.1242/jcs.02383. PMID 15944398.

ARHGAP8

References

Further reading