ARHGAP5

Rho GTPase activating protein 5

Rendering based on PDB 2EE4.

Available structures
PDB	2EE4, 2EE5

Identifiers

Symbols

ARHGAP5; GFI2; RhoGAP5; p190-B; p190BRhoGAP

External IDs

OMIM: 602680 MGI: 1332637 HomoloGene: 907 GeneCards: ARHGAP5 Gene

Gene Ontology
Molecular function	• GTPase activity • GTPase activator activity • Rho GTPase activator activity • GTP binding • SH2 domain binding
Cellular component	• intracellular • cytoplasm • cytosol • membrane
Biological process	• GTP catabolic process • cell adhesion • signal transduction • small GTPase mediated signal transduction • Rho protein signal transduction • positive regulation of Rho GTPase activity • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
32.55 – 32.63 Mb

Chr 12:
53.62 – 53.67 Mb

PubMed search

[1]

[2]

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.^[1]^[2]

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

ARHGAP5 has been shown to interact with Rnd1,^[3] Rnd2,^[3] Rnd3^[3] and RHOA.^[3]

References

^ Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (Feb 1996). "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking". J Biol Chem 270 (52): 30919–26. doi:10.1074/jbc.270.52.30919. PMID 8537347.
^ ^a ^b "Entrez Gene: ARHGAP5 Rho GTPase activating protein 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=394.
^ ^a ^b ^c ^d Wennerberg, Krister; Forget Marie-Annick, Ellerbroek Shawn M, Arthur William T, Burridge Keith, Settleman Jeffrey, Der Channing J, Hansen Steen H (Jul. 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. (England) 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009.

Ellis C, Moran M, McCormick F, Pawson T (1990). "Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases". Nature 343 (6256): 377–81. doi:10.1038/343377a0. PMID 1689011.
Foster R, Hu KQ, Shaywitz DA, Settleman J (1994). "p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly". Mol. Cell. Biol. 14 (11): 7173–81. PMC 359251. PMID 7935432. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359251.
McGlade J, Brunkhorst B, Anderson D, et al. (1993). "The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion". EMBO J. 12 (8): 3073–81. PMC 413572. PMID 8344248. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=413572.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zrihan-Licht S, Fu Y, Settleman J, et al. (2000). "RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion". Oncogene 19 (10): 1318–28. doi:10.1038/sj.onc.1203422. PMID 10713673.
Kulkarni SV, Gish G, van der Geer P, et al. (2000). "Role of P120 Ras-Gap in Directed Cell Movement". J. Cell Biol. 149 (2): 457–70. doi:10.1083/jcb.149.2.457. PMC 2175152. PMID 10769036. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175152.
Chakravarty G, Roy D, Gonzales M, et al. (2000). "P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer". Cell Growth Differ. 11 (7): 343–54. PMID 10939588.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Shiota M, Tanihiro T, Nakagawa Y, et al. (2004). "Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone". Mol. Endocrinol. 17 (4): 534–49. doi:10.1210/me.2002-0187. PMID 12554790.
Wennerberg K, Forget MA, Ellerbroek SM, et al. (2004). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. PMID 12842009.
Su L, Agati JM, Parsons SJ (2004). "p190RhoGAP is cell cycle regulated and affects cytokinesis". J. Cell Biol. 163 (3): 571–82. doi:10.1083/jcb.200308007. PMC 2173658. PMID 14610059. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173658.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
Vargo-Gogola T, Heckman BM, Gunther EJ, et al. (2006). "P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland". Mol. Endocrinol. 20 (6): 1391–405. doi:10.1210/me.2005-0426. PMID 16469769.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.

ARHGAP5

Interactions

References

Further reading