ARFGEF1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.[1][2][3]
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.[3]
Interactions
ARFGEF1 has been shown to interact with FKBP2,[4] ARFGEF2[5] and PRKAR1A.[6]
References
- ^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Jun 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". J Biol Chem 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
- ^ Morinaga N, Tsai SC, Moss J, Vaughan M (Dec 1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain". Proc Natl Acad Sci U S A 93 (23): 12856–60. doi:10.1073/pnas.93.23.12856. PMC 24010. PMID 8917509. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24010.
- ^ a b "Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10565.
- ^ Padilla, Philip Ian; Chang Min-Ju, Pacheco-Rodriguez Gustavo, Adamik Ronald, Moss Joel, Vaughan Martha (Mar. 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (5): 2322–7. doi:10.1073/pnas.2628047100. ISSN 0027-8424. PMC 151339. PMID 12606707. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151339.
- ^ Yamaji, R; Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans V J, Moss J, Vaughan M (Mar. 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. ISSN 0027-8424. PMC 15969. PMID 10716990. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15969.
- ^ Li, Hewang; Adamik Ronald, Pacheco-Rodriguez Gustavo, Moss Joel, Vaughan Martha (Feb. 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (4): 1627–32. doi:10.1073/pnas.0337678100. ISSN 0027-8424. PMC 149883. PMID 12571360. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149883.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Mansour SJ, Skaug J, Zhao XH et al. (1999). "p200 ARF–GEP1: A Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 7968–73. doi:10.1073/pnas.96.14.7968. PMC 22171. PMID 10393931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22171.
- Yamaji R, Adamik R, Takeda K et al. (2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15969.
- Kamei Y, Takeda Y, Teramoto K et al. (2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
- Padilla PI, Chang MJ, Pacheco-Rodriguez G et al. (2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMC 151339. PMID 12606707. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151339.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (2004). "Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2752–7. doi:10.1073/pnas.0307345101. PMC 365693. PMID 14973189. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=365693.
- Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". J. Biol. Chem. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.
- Citterio C, Jones HD, Pacheco-Rodriguez G et al. (2006). "Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei". Proc. Natl. Acad. Sci. U.S.A. 103 (8): 2683–8. doi:10.1073/pnas.0510571103. PMC 1413798. PMID 16467138. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1413798.
- Belov GA, Altan-Bonnet N, Kovtunovych G et al. (2007). "Hijacking Components of the Cellular Secretory Pathway for Replication of Poliovirus RNA". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456. PMID 17079330. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1797456.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Shen X, Hong MS, Moss J, Vaughan M (2007). "BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin β1". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1230–5. doi:10.1073/pnas.0610535104. PMC 1783117. PMID 17227842. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1783117.
- Kuroda F, Moss J, Vaughan M (2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1γ". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMC 1805514. PMID 17360629. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1805514.