ARD1A

N(alpha)-acetyltransferase 10, NatA catalytic subunit

Identifiers

NAA10; ARD1; ARD1A; DXS707; MGC71248; TE2

External IDs

OMIM: 300013 MGI: 1915255 HomoloGene: 2608 GeneCards: NAA10 Gene

2.3.1.88

Gene Ontology
Molecular function	• peptide alpha-N-acetyltransferase activity • protein binding • N-acetyltransferase activity • acetyltransferase activity • transferase activity • ribosome binding
Cellular component	• intracellular • nucleus • cytoplasm
Biological process	• DNA packaging • N-terminal protein amino acid acetylation • internal protein amino acid acetylation • metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
153.19 – 153.2 Mb

Chr X:
71.16 – 71.17 Mb

PubMed search

[1]

[2]

N-terminal acetyltransferase complex ARD1 subunit homolog A is an enzyme that in humans is encoded by the ARD1A gene.^[1]^[2]

References

^ Tribioli C, Mancini M, Plassart E, Bione S, Rivella S, Sala C, Torri G, Toniolo D (Jan 1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae". Hum Mol Genet 3 (7): 1061–7. doi:10.1093/hmg/3.7.1061. PMID 7981673.
^ "Entrez Gene: ARD1A ARD1 homolog A, N-acetyltransferase (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8260.

Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
Jeong JW, Bae MK, Ahn MY, et al. (2003). "Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.". Cell 111 (5): 709–20. doi:10.1016/S0092-8674(02)01085-1. PMID 12464182.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Sugiura N, Adams SM, Corriveau RA (2003). "An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development.". J. Biol. Chem. 278 (41): 40113–20. doi:10.1074/jbc.M301218200. PMID 12888564.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Arnesen T, Anderson D, Baldersheim C, et al. (2005). "Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.". Biochem. J. 386 (Pt 3): 433–43. doi:10.1042/BJ20041071. PMC 1134861. PMID 15496142. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134861.
Asaumi M, Iijima K, Sumioka A, et al. (2005). "Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion.". J. Biochem. 137 (2): 147–55. doi:10.1093/jb/mvi014. PMID 15749829.
Fisher TS, Etages SD, Hayes L, et al. (2005). "Analysis of ARD1 function in hypoxia response using retroviral RNA interference.". J. Biol. Chem. 280 (18): 17749–57. doi:10.1074/jbc.M412055200. PMID 15755738.
Bilton R, Mazure N, Trottier E, et al. (2005). "Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF.". J. Biol. Chem. 280 (35): 31132–40. doi:10.1074/jbc.M504482200. PMID 15994306.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Arnesen T, Gromyko D, Horvli O, et al. (2006). "Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.". Thyroid 15 (10): 1131–6. doi:10.1089/thy.2005.15.1131. PMID 16279846.
Arnesen T, Kong X, Evjenth R, et al. (2006). "Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha.". FEBS Lett. 579 (28): 6428–32. doi:10.1016/j.febslet.2005.10.036. PMID 16288748.
Kim SH, Park JA, Kim JH, et al. (2006). "Characterization of ARD1 variants in mammalian cells.". Biochem. Biophys. Res. Commun. 340 (2): 422–7. doi:10.1016/j.bbrc.2005.12.018. PMID 16376303.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Arnesen T, Gromyko D, Pendino F, et al. (2006). "Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.". Oncogene 25 (31): 4350–60. doi:10.1038/sj.onc.1209469. PMID 16518407.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.

ARD1A

References

Further reading