APOBEC1

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Identifiers

APOBEC1; APOBEC-1; BEDP; CDAR1; HEPR

External IDs

OMIM: 600130 MGI: 103298 HomoloGene: 1243 GeneCards: APOBEC1 Gene

3.5.4.-

Gene Ontology
Molecular function	• RNA binding • cytidine deaminase activity • zinc ion binding • hydrolase activity • metal ion binding
Cellular component	• nucleoplasm
Biological process	• RNA processing • mRNA processing • lipid metabolic process • response to osmotic stress • cytidine deamination • response to zinc ion • cytidine to uridine editing • mRNA modification • cellular response to insulin stimulus • response to drug • response to ethanol • response to calcium ion • defense response to virus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
7.8 – 7.82 Mb

Chr 6:
122.53 – 122.55 Mb

PubMed search

[1]

[2]

C->U-editing enzyme APOBEC-1 is a protein that in humans is encoded by the APOBEC1 gene.^[1]

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.^[1]

Interactions

APOBEC1 has been shown to interact with SYNCRIP,^[2] ACF^[3]^[4] and BAG4.^[5]

References

^ ^a ^b "Entrez Gene: APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=339.
^ Lau, P P; Chang B H, Chan L (Apr. 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochem. Biophys. Res. Commun. (United States) 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. ISSN 0006-291X. PMID 11352648.
^ Blanc, V; Navaratnam N, Henderson J O, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson N O (Mar. 2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". J. Biol. Chem. (United States) 276 (13): 10272–83. doi:10.1074/jbc.M006435200. ISSN 0021-9258. PMID 11134005.
^ Mehta, A; Kinter M T, Sherman N E, Driscoll D M (Mar. 2000). "Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNA". Mol. Cell. Biol. (UNITED STATES) 20 (5): 1846–54. doi:10.1128/MCB.20.5.1846-1854.2000. ISSN 0270-7306. PMC 85365. PMID 10669759. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85365.
^ Lau, Paul P; Chan Lawrence (Dec. 2003). "Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing". J. Biol. Chem. (United States) 278 (52): 52988–96. doi:10.1074/jbc.M310153200. ISSN 0021-9258. PMID 14559896.

Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
Harris RS, Liddament MT (2004). "Retroviral restriction by APOBEC proteins". Nat. Rev. Immunol. 4 (11): 868–77. doi:10.1038/nri1489. PMID 15516966.
Espinosa R, Funahashi T, Hadjiagapiou C, et al. (1995). "Assignment of the gene encoding the human apolipoprotein B mRNA editing enzyme (APOBEC1) to chromosome 12p13.1". Genomics 24 (2): 414–5. doi:10.1006/geno.1994.1645. PMID 7698776.
Navaratnam N, Bhattacharya S, Fujino T, et al. (1995). "Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site". Cell 81 (2): 187–95. doi:10.1016/0092-8674(95)90328-3. PMID 7736571.
Lau PP, Zhu HJ, Baldini A, et al. (1994). "Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8522–6. doi:10.1073/pnas.91.18.8522. PMC 44638. PMID 8078915. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44638.
Hadjiagapiou C, Giannoni F, Funahashi T, et al. (1994). "Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein". Nucleic Acids Res. 22 (10): 1874–9. doi:10.1093/nar/22.10.1874. PMC 308087. PMID 8208612. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=308087.
Morrison JR, Pászty C, Stevens ME, et al. (1996). "Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7154–9. doi:10.1073/pnas.93.14.7154. PMC 38952. PMID 8692961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38952.
Lau PP, Zhu HJ, Nakamuta M, Chan L (1997). "Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing". J. Biol. Chem. 272 (3): 1452–5. doi:10.1074/jbc.272.3.1452. PMID 8999813.
Oka K, Kobayashi K, Sullivan M, et al. (1997). "Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice". J. Biol. Chem. 272 (3): 1456–60. doi:10.1074/jbc.272.3.1456. PMID 8999814.
Hirano K, Min J, Funahashi T, et al. (1997). "Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide". J. Lipid Res. 38 (5): 847–59. PMID 9186903.
Fujino T, Navaratnam N, Scott J (1998). "Human apolipoprotein B RNA editing deaminase gene (APOBEC1)". Genomics 47 (2): 266–75. doi:10.1006/geno.1997.5110. PMID 9479499.
Mehta A, Kinter MT, Sherman NE, Driscoll DM (2000). "Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNA". Mol. Cell. Biol. 20 (5): 1846–54. doi:10.1128/MCB.20.5.1846-1854.2000. PMC 85365. PMID 10669759. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85365.
Lellek H, Kirsten R, Diehl I, et al. (2000). "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex". J. Biol. Chem. 275 (26): 19848–56. doi:10.1074/jbc.M001786200. PMID 10781591.
Blanc V, Navaratnam N, Henderson JO, et al. (2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". J. Biol. Chem. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005.
Lau PP, Chang BH, Chan L (2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochem. Biophys. Res. Commun. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. PMID 11577082.
Lau PP, Villanueva H, Kobayashi K, et al. (2002). "A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing". J. Biol. Chem. 276 (49): 46445–52. doi:10.1074/jbc.M109215200. PMID 11584023.
Anant S, Mukhopadhyay D, Sankaranand V, et al. (2001). "ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing". Am. J. Physiol., Cell Physiol. 281 (6): C1904–16. PMID 11698249.
Mukhopadhyay D, Anant S, Lee RM, et al. (2002). "C→U Editing of Neurofibromatosis 1 mRNA Occurs in Tumors That Express Both the Type II Transcript and apobec-1, the Catalytic Subunit of the Apolipoprotein B mRNA–Editing Enzyme". Am. J. Hum. Genet. 70 (1): 38–50. doi:10.1086/337952. PMC 384902. PMID 11727199. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384902.
Dance GS, Sowden MP, Cartegni L, et al. (2002). "Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing". J. Biol. Chem. 277 (15): 12703–9. doi:10.1074/jbc.M111337200. PMID 11815617.

APOBEC1

Interactions

References

Further reading