APOA5

Apolipoprotein A-V

Identifiers

APOA5; APOAV; FLJ97995; MGC126836; MGC126838; RAP3

External IDs

OMIM: 606368 MGI: 1913363 HomoloGene: 14197 GeneCards: APOA5 Gene

Gene Ontology
Molecular function	• protein binding • phospholipid binding • enzyme activator activity • heparin binding • heparin binding • lipid binding • enzyme binding • phosphatidylcholine binding • low-density lipoprotein particle receptor binding • lipase activator activity • lipoprotein lipase activator activity • lipoprotein particle receptor binding
Cellular component	• extracellular region • extracellular space • very-low-density lipoprotein particle • low-density lipoprotein particle • high-density lipoprotein particle • chylomicron
Biological process	• triglyceride metabolic process • triglyceride metabolic process • transport • lipid transport • response to hormone stimulus • positive regulation of triglyceride catabolic process • positive regulation of very-low-density lipoprotein particle remodeling • triglyceride catabolic process • organ regeneration • triglyceride-rich lipoprotein particle remodeling • lipoprotein metabolic process • tissue regeneration • cholesterol homeostasis • cellular lipid metabolic process • positive regulation of fatty acid biosynthetic process • positive regulation of receptor-mediated endocytosis • positive regulation of lipid catabolic process • positive regulation of lipoprotein lipase activity • acylglycerol homeostasis • acylglycerol homeostasis • triglyceride homeostasis • triglyceride homeostasis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
116.66 – 116.66 Mb

Chr 9:
46.08 – 46.08 Mb

PubMed search

[1]

[2]

Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene.^[1]^[2]^[3]

The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.^[4]

This gene uses alternate polyadenylation sites and is located proximal to the apolipoprotein gene cluster on chromosome 11q23.^[3]

1 Interactive pathway map
2 See also
3 References
4 Further reading

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^[5]

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Statin Pathway edit

References

^ Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM (Oct 2001). "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing". Science 294 (5540): 169–73. doi:10.1126/science.1064852. PMID 11588264.
^ van der Vliet HN, Sammels MG, Leegwater AC, Levels JH, Reitsma PH, Boers W, Chamuleau RA (Nov 2001). "Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration". J Biol Chem 276 (48): 44512–20. doi:10.1074/jbc.M106888200. PMID 11577099.
^ ^a ^b "Entrez Gene: APOA5 apolipoprotein A-V". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116519.
^ Nilsson SK, Christensen S, Raarup MK, Ryan RO, Nielsen MS, Olivecrona G (July 2008). "Endocytosis of Apolipoprotein A-V by Members of the Low Density Lipoprotein Receptor and the Vps10p Domain Receptor Families". J. Biol. Chem. 283 (38): 25920–7. doi:10.1074/jbc.M802721200. PMC 2533778. PMID 18603531. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2533778.
^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". http://www.wikipathways.org/index.php/Pathway:WP430.

Pennacchio LA, Rubin EM (2004). "Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice". Arterioscler. Thromb. Vasc. Biol. 23 (4): 529–34. doi:10.1161/01.ATV.0000054194.78240.45. PMID 12615678.
Jakel H, Nowak M, Helleboid-Chapman A, et al. (2006). "Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins?". Ann. Med. 38 (1): 2–10. doi:10.1080/07853890500407488. PMID 16448983.
Calandra S, Priore Oliva C, Tarugi P, Bertolini S (2007). "APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency". Curr. Opin. Lipidol. 17 (2): 122–7. doi:10.1097/01.mol.0000217892.00618.54. PMID 16531747.
Wong K, Ryan RO (2007). "Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation". Curr. Opin. Lipidol. 18 (3): 319–24. doi:10.1097/MOL.0b013e328133856c. PMID 17495607.
Nabika T, Nasreen S, Kobayashi S, Masuda J (2003). "The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese". Atherosclerosis 165 (2): 201–4. doi:10.1016/S0021-9150(02)00252-6. PMID 12417270.
Pennacchio LA, Olivier M, Hubacek JA, et al. (2003). "Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels". Hum. Mol. Genet. 11 (24): 3031–8. doi:10.1093/hmg/11.24.3031. PMID 12417524.
Talmud PJ, Hawe E, Martin S, et al. (2003). "Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides". Hum. Mol. Genet. 11 (24): 3039–46. doi:10.1093/hmg/11.24.3039. PMID 12417525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Vu-Dac N, Gervois P, Jakel H, et al. (2003). "Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators". J. Biol. Chem. 278 (20): 17982–5. doi:10.1074/jbc.M212191200. PMID 12637506.
Prieur X, Coste H, Rodriguez JC (2003). "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element". J. Biol. Chem. 278 (28): 25468–80. doi:10.1074/jbc.M301302200. PMID 12709436.
Weinberg RB, Cook VR, Beckstead JA, et al. (2003). "Structure and interfacial properties of human apolipoprotein A-V". J. Biol. Chem. 278 (36): 34438–44. doi:10.1074/jbc.M303784200. PMID 12810715.
Horínek A, Vráblík M, Ceska R, et al. (2003). "T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals". Atherosclerosis 167 (2): 369–70. doi:10.1016/S0021-9150(03)00022-4. PMID 12818421.
Beckstead JA, Oda MN, Martin DD, et al. (2003). "Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis". Biochemistry 42 (31): 9416–23. doi:10.1021/bi034509t. PMID 12899628.
Kao JT, Wen HC, Chien KL, et al. (2004). "A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia". Hum. Mol. Genet. 12 (19): 2533–9. doi:10.1093/hmg/ddg255. PMID 12915450.
Vrablík M, Horínek A, Ceska R, et al. (2003). "Ser19→Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people". J. Med. Genet. 40 (8): e105. doi:10.1136/jmg.40.8.e105. PMC 1735562. PMID 12920097. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1735562.
Lai CQ, Tai ES, Tan CE, et al. (2004). "The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore". J. Lipid Res. 44 (12): 2365–73. doi:10.1194/jlr.M300251-JLR200. PMID 12951359.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.