APOA2
| ApoA-II |
|
| structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions |
| Identifiers |
| Symbol |
ApoA-II |
| Pfam |
PF04711 |
| InterPro |
IPR006801 |
| SCOP |
1l6k |
|
|
Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[1]
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[2]
Interactions
APOA2 has been shown to interact with PLTP.[3]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [4]
References
- ^ Tsao YK, Wei CF, Robberson DL, Gotto AM Jr, Chan L (Jan 1986). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". J Biol Chem 260 (28): 15222–31. PMID 2415515.
- ^ "Entrez Gene: APOA2 apolipoprotein A-II". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=336.
- ^ Pussinen, P J; Jauhiainen M, Metso J, Pyle L E, Marcel Y L, Fidge N H, Ehnholm C (Jan. 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. (UNITED STATES) 39 (1): 152–61. ISSN 0022-2275. PMID 9469594.
- ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". http://www.wikipathways.org/index.php/Pathway:WP430.
Further reading
- Blanco-Vaca F, Escolà-Gil JC, Martín-Campos JM, Julve J (2002). "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein.". J. Lipid Res. 42 (11): 1727–39. PMID 11714842.
- Kalopissis AD, Pastier D, Chambaz J (2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance.". Curr. Opin. Lipidol. 14 (2): 165–72. doi:10.1097/01.mol.0000064047.08840.50. PMID 12642785.
- Vollmer E, Brust J, Roessner A, et al. (1991). "Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels.". Virchows Archiv. A, Pathological anatomy and histopathology 419 (2): 79–88. doi:10.1007/BF01600220. PMID 1908160.
- Deeb SS, Takata K, Peng RL, et al. (1990). "A splice-junction mutation responsible for familial apolipoprotein A-II deficiency.". Am. J. Hum. Genet. 46 (4): 822–7. PMC 1683675. PMID 2107739. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1683675.
- Gordon JI, Sims HF, Edelstein C, et al. (1985). "Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B.". J. Biol. Chem. 260 (27): 14824–31. PMID 2414299.
- Lackner KJ, Law SW, Brewer HB (1985). "The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization.". Nucleic Acids Res. 13 (12): 4597–608. doi:10.1093/nar/13.12.4597. PMC 321808. PMID 2989800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=321808.
- Knott TJ, Wallis SC, Robertson ME, et al. (1985). "The human apolipoprotein AII gene: structural organization and sites of expression.". Nucleic Acids Res. 13 (17): 6387–98. doi:10.1093/nar/13.17.6387. PMC 321960. PMID 2995928. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=321960.
- Chan L, Moore MN, Tsao YK (1986). [43] Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA. "Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA.". Meth. Enzymol.. Methods in Enzymology 128: 745–52. doi:10.1016/0076-6879(86)28103-3. ISBN 9780121820282. PMID 3088392.
- Middleton-Price HR, van den Berghe JA, Scott J, et al. (1988). "Regional chromosomal localisation of APOA2 to 1q21-1q23". Hum. Genet. 79 (3): 283–5. doi:10.1007/BF00366253. PMID 3136074.
- Shelley CS, Sharpe CR, Baralle FE, Shoulders CC (1986). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction". J. Mol. Biol. 186 (1): 43–51. doi:10.1016/0022-2836(85)90255-4. PMID 3935800.
- Brewer HB, Lux SE, Ronan R, John KM (1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex". Proc. Natl. Acad. Sci. U.S.A. 69 (5): 1304–8. doi:10.1073/pnas.69.5.1304. PMC 426687. PMID 4338591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=426687.
- Lux SE, John KM, Ronan R, Brewer HB (1973). "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein". J. Biol. Chem. 247 (23): 7519–27. PMID 4344225.
- Moore MN, Kao FT, Tsao YK, Chan L (1984). "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1". Biochem. Biophys. Res. Commun. 123 (1): 1–7. doi:10.1016/0006-291X(84)90371-1. PMID 6089788.
- Lackner KJ, Law SW, Brewer HB (1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II". FEBS Lett. 175 (1): 159–64. doi:10.1016/0014-5793(84)80590-6. PMID 6090207.
- Gordon JI, Budelier KA, Sims HF, et al. (1984). "Biosynthesis of human preproapolipoprotein A-II". J. Biol. Chem. 258 (22): 14054–9. PMID 6315718.
- Sharpe CR, Sidoli A, Shelley CS, et al. (1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Res. 12 (9): 3917–32. doi:10.1093/nar/12.9.3917. PMC 318799. PMID 6328445. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=318799.
- Stoffel W, Krüger E, Deutzmann R (1983). "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products". Hoppe-Seyler's Z. Physiol. Chem. 364 (3): 227–37. PMID 6407957.
- Knott TJ, Priestley LM, Urdea M, Scott J (1984). "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII". Biochem. Biophys. Res. Commun. 120 (3): 734–40. doi:10.1016/S0006-291X(84)80168-0. PMID 6428397.
- Lackner KJ, Law SW, Brewer HB, et al. (1984). "The human apolipoprotein A-II gene is located on chromosome 1". Biochem. Biophys. Res. Commun. 122 (3): 877–83. doi:10.1016/0006-291X(84)91172-0. PMID 6433912.