APBB1IP

Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein

Identifiers

APBB1IP; INAG1; PREL1; RARP1; RIAM

External IDs

OMIM: 609036 MGI: 1861354 HomoloGene: 32434 GeneCards: APBB1IP Gene

Gene Ontology
Molecular function	• structural molecule activity
Cellular component	• cytoplasm • cytosol • cytosol • cytoskeleton • plasma membrane • focal adhesion • lamellipodium • cell junction
Biological process	• signal transduction • blood coagulation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
26.73 – 26.86 Mb

Chr 2:
22.63 – 22.73 Mb

PubMed search

[1]

[2]

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.^[1]^[2]^[3]

References

^ "Entrez Gene: amyloid beta (A4) precursor protein-binding". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54518.
^ Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (December 2003). "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". J. Biol. Chem. 278 (51): 51685–92. doi:10.1074/jbc.M308016200. PMID 14530287.
^ Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (October 2004). "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion". Dev. Cell 7 (4): 585–95. doi:10.1016/j.devcel.2004.07.021. PMID 15469846.

Lee HS, Lim CJ, Puzon-McLaughlin W, et al. (2009). "RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.". J. Biol. Chem. 284 (8): 5119–27. doi:10.1074/jbc.M807117200. PMID 19098287.
Ermekova KS, Zambrano N, Linn H, et al. (1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.". J. Biol. Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
Rose JE, Behm FM, Drgon T, et al.. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896464.
Morgan AR, Turic D, Jehu L, et al. (2007). "Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6): 762–70. doi:10.1002/ajmg.b.30509. PMID 17373700.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Jenzora A, Behrendt B, Small JV, et al. (2005). "PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.". FEBS Lett. 579 (2): 455–63. doi:10.1016/j.febslet.2004.10.110. PMID 15642358.
Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1380225.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Patsoukis N, Lafuente EM, Meraner P, et al. (2009). "RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.". Sci Signal 2 (99): ra79. doi:10.1126/scisignal.2000409. PMID 19952372.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Linkermann A, Gelhaus C, Lettau M, et al. (2009). "Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.". Biochim. Biophys. Acta 1794 (2): 168–76. doi:10.1016/j.bbapap.2008.10.013. PMID 19041431.
Defilippi P, Di Stefano P, Cabodi S (2006). "p130Cas: a versatile scaffold in signaling networks.". Trends Cell Biol. 16 (5): 257–63. doi:10.1016/j.tcb.2006.03.003. PMID 16581250.
Shattil SJ (2005). "Integrins and Src: dynamic duo of adhesion signaling.". Trends Cell Biol. 15 (8): 399–403. doi:10.1016/j.tcb.2005.06.005. PMID 16005629.

APBB1IP

References

Further reading