AP3S1

Adaptor-related protein complex 3, sigma 1 subunit

Identifiers

AP3S1; CLAPS3; Sigma3A

External IDs

OMIM: 601507 MGI: 1337062 HomoloGene: 4254 GeneCards: AP3S1 Gene

Gene Ontology
Molecular function	• transporter activity • protein binding • protein transporter activity
Cellular component	• Golgi apparatus • membrane • AP-type membrane coat adaptor complex • transport vesicle • cytoplasmic vesicle membrane • cytoplasmic vesicle
Biological process	• transport • intracellular protein transport • insulin receptor signaling pathway • vesicle-mediated transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000177879

ENSMUSG00000024480

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
115.18 – 115.25 Mb

Chr 18:
46.9 – 46.95 Mb

PubMed search

AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.^[1]^[2]^[3]

References

^ Watanabe TK, Shimizu F, Nagata M, Takaichi A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Sep 1996). "Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain". Cytogenet Cell Genet 73 (3): 214–7. doi:10.1159/000134341. PMID 8697810.
^ Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (Apr 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC 1169692. PMID 9118953. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169692.
^ "Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1176.

Further reading

Simpson F, Peden AA, Christopoulou L, Robinson MS (1997). "Characterization of the adaptor-related protein complex, AP-3.". J. Cell Biol. 137 (4): 835–45. doi:10.1083/jcb.137.4.835. PMC 2139840. PMID 9151686. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139840.
VanRenterghem B, Morin M, Czech MP, Heller-Harrison RA (1998). "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes.". J. Biol. Chem. 273 (45): 29942–9. doi:10.1074/jbc.273.45.29942. PMID 9792713.
Rodionov DG, Höning S, Silye A, et al. (2003). "Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3.". J. Biol. Chem. 277 (49): 47436–43. doi:10.1074/jbc.M207149200. PMID 12370188.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Nie Z, Boehm M, Boja ES, et al. (2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.". Dev. Cell 5 (3): 513–21. doi:10.1016/S1534-5807(03)00234-X. PMID 12967569.
Salazar G, Love R, Werner E, et al. (2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.". Mol. Biol. Cell 15 (2): 575–87. doi:10.1091/mbc.E03-06-0401. PMC 329249. PMID 14657250. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=329249.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lefrançois S, Janvier K, Boehm M, et al. (2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes.". Dev. Cell 7 (4): 619–25. doi:10.1016/j.devcel.2004.08.009. PMID 15469849.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.