| Acyloxyacyl hydrolase (neutrophil) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | AOAH; | ||||||||||||
| External IDs | OMIM: 102593 MGI: 1350928 HomoloGene: 1238 GeneCards: AOAH Gene | ||||||||||||
| EC number | 3.1.1.77 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 313 | 27052 | |||||||||||
| Ensembl | ENSG00000136250 | ENSMUSG00000021322 | |||||||||||
| UniProt | P28039 | O35298 | |||||||||||
| RefSeq (mRNA) | NM_001177506.1 | NM_012054.3 | |||||||||||
| RefSeq (protein) | NP_001170977.1 | NP_036184.1 | |||||||||||
| Location (UCSC) | Chr 7: 36.55 – 36.76 Mb |
Chr 13: 20.89 – 21.12 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Acyloxyacyl hydrolase (neutrophil), also known as AOAH, is a protein which in humans is encoded by the AOAH gene.[1][2]
Acyloxyacyl hydrolase (AOAH) is a 2-subunit lipase which selectively hydrolyzes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPSs, also called endotoxins). This action inactivates LPSs that are sensed by MD-2--Toll-like Receptor 4 (TLR 4) on animal cells. AOAH prevents prolonged host inflammatory responses to gram-negative bacterial diseases. Its 2 disulfide-linked subunits are encoded by a single mRNA. The smaller subunit is a member of the saposin-like (SAPLIP) proteins and the larger subunit is a GDSL lipase. [1]
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