ANAPC11

Anaphase promoting complex subunit 11

Identifiers

ANAPC11; APC11; Apc11p; MGC882

External IDs

MGI: 1913406 HomoloGene: 41136 GeneCards: ANAPC11 Gene

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • zinc ion binding • metal ion binding
Cellular component	• nucleus • nucleoplasm • nucleoplasm • anaphase-promoting complex • cytoplasm • cytosol • cytosol
Biological process	• cell cycle checkpoint • mitotic cell cycle • mitosis • mitotic cell cycle spindle assembly checkpoint • protein ubiquitination • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cell division • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein K11-linked ubiquitination
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000141552

ENSMUSG00000025135

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
79.85 – 79.86 Mb

Chr 11:
120.46 – 120.47 Mb

PubMed search

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.^[1]^[2]

Interactions

ANAPC11 has been shown to interact with ANAPC2^[3]^[4] and CDC27.^[1]^[5]

References

^ ^a ^b Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Sep 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc Natl Acad Sci U S A 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16806.
^ "Entrez Gene: ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51529.
^ Tang, Z; Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (Dec. 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell (United States) 12 (12): 3839–51. ISSN 1059-1524. PMC 60759. PMID 11739784. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60759.
^ Ohta, T; Michel J J, Schottelius A J, Xiong Y (Apr. 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell (UNITED STATES) 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407.
^ Vodermaier, Hartmut C; Gieffers Christian, Maurer-Stroh Sebastian, Eisenhaber Frank, Peters Jan-Michael (Sep. 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. (England) 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Chang TS, Jeong W, Lee DY, et al. (2005). "The RING-H2-finger protein APC11 as a target of hydrogen peroxide.". Free Radic. Biol. Med. 37 (4): 521–30. doi:10.1016/j.freeradbiomed.2004.05.006. PMID 15256223.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.". Mol. Biol. Cell 12 (12): 3839–51. PMC 60759. PMID 11739784. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60759.
Chan AH, Lee SM, Chim SS, et al. (2001). "Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p.". J. Cell. Biochem. 83 (2): 249–58. doi:10.1002/jcb.1217. PMID 11573242.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.