ALX1
ALX homeobox protein 1 is a protein that in humans is encoded by the ALX1 gene.[1][2][3]
The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly.[3]
Interactions
ALX1 has been shown to interact with IPO13.[4]
References
- ^ Gordon DF, Wagner J, Atkinson BL, Chiono M, Berry R, Sikela J, Gutierrez-Hartmann A (Sep 1996). "Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA". DNA Cell Biol 15 (7): 531–41. doi:10.1089/dna.1996.15.531. PMID 8756334.
- ^ Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (Dec 1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma". J Biol Chem 270 (43): 25715–21. doi:10.1074/jbc.270.43.25715. PMID 7592751.
- ^ a b "Entrez Gene: CART1 cartilage paired-class homeoprotein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8092.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Zhao GQ, Zhou X, Eberspaecher H, et al. (1993). "Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes.". Proc. Natl. Acad. Sci. U.S.A. 90 (18): 8633–7. doi:10.1073/pnas.90.18.8633. PMC 47412. PMID 7690966. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47412.
- Zhao Q, Behringer RR, de Crombrugghe B (1996). "Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene.". Nat. Genet. 13 (3): 275–83. doi:10.1038/ng0796-275. PMID 8673125.
- Cai RL (1998). "Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites.". Biochem. Biophys. Res. Commun. 250 (2): 305–11. doi:10.1006/bbrc.1998.9257. PMID 9753625.
- Qu S, Tucker SC, Zhao Q, et al. (1999). "Physical and genetic interactions between Alx4 and Cart1.". Development 126 (2): 359–69. PMID 9847249.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Iioka T, Furukawa K, Yamaguchi A, et al. (2004). "P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.". J. Bone Miner. Res. 18 (8): 1419–29. doi:10.1359/jbmr.2003.18.8.1419. PMID 12929931.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.