ALS2CR2
STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.[1][2][3]
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.[3]
Interactions
ALS2CR2 has been shown to interact with XIAP.[4]
References
- ^ Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Feb 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
- ^ Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG (Jul 2004). "Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". J Biol 2 (4): 28. doi:10.1186/1475-4924-2-28. PMC 333410. PMID 14511394. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=333410.
- ^ a b "Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55437.
- ^ Sanna, M Germana; da Silva Correia Jean, Luo Ying, Chuang Betty, Paulson Lorien M, Nguyen Binh, Deveraux Quinn L, Ulevitch Richard J (Aug. 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". J. Biol. Chem. (United States) 277 (34): 30454–62. doi:10.1074/jbc.M203312200. ISSN 0021-9258. PMID 12048196.
Further reading
- Alessi DR, Sakamoto K, Bayascas JR (2007). "LKB1-dependent signaling pathways". Annu. Rev. Biochem. 75: 137–63. doi:10.1146/annurev.biochem.75.103004.142702. PMID 16756488.
- Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR (2006). "Emerging roles of pseudokinases". Trends Cell Biol. 16 (9): 443–52. doi:10.1016/j.tcb.2006.07.003. PMID 16879967.
- Sanna MG, da Silva Correia J, Luo Y, et al. (2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". J. Biol. Chem. 277 (34): 30454–62. doi:10.1074/jbc.M203312200. PMID 12048196.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Nishigaki K, Thompson D, Yugawa T, et al. (2003). "Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase". J. Biol. Chem. 278 (15): 13520–30. doi:10.1074/jbc.M208601200. PMID 12574163.
- Boudeau J, Baas AF, Deak M, et al. (2003). "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=204473.
- Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.