ALOX15
Arachidonate 15-lipoxygenase is an enzyme that in humans is encoded by the ALOX15 gene.[1]
References
Further reading
- Kelavkar U, Glasgow W, Eling TE (2003). "The effect of 15-lipoxygenase-1 expression on cancer cells". Current urology reports 3 (3): 207–14. doi:10.1007/s11934-002-0066-8. PMID 12084190.
- Sigal E, Dicharry S, Highland E, Finkbeiner WE (1992). "Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium". Am. J. Physiol. 262 (4 Pt 1): L392–8. PMID 1566855.
- Izumi T, Rådmark O, Jörnvall H, Samuelsson B (1992). "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes". Eur. J. Biochem. 202 (3): 1231–8. doi:10.1111/j.1432-1033.1991.tb16495.x. PMID 1662607.
- Conrad DJ, Kuhn H, Mulkins M et al. (1992). "Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 217–21. doi:10.1073/pnas.89.1.217. PMC 48207. PMID 1729692. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48207.
- Lei ZM, Rao CV (1992). "The expression of 15-lipoxygenase gene and the presence of functional enzyme in cytoplasm and nuclei of pregnancy human myometria". Endocrinology 130 (2): 861–70. doi:10.1210/en.130.2.861. PMID 1733732.
- Izumi T, Rådmark O, Samuelsson B (1991). "Purification of 15-lipoxygenase from human leukocytes, evidence for the presence of isozymes". Adv. Prostaglandin Thromboxane Leukot. Res. 21A: 101–4. PMID 1825526.
- Sloane DL, Leung R, Craik CS, Sigal E (1991). "A primary determinant for lipoxygenase positional specificity". Nature 354 (6349): 149–52. doi:10.1038/354149a0. PMID 1944593.
- Nadel JA, Conrad DJ, Ueki IF et al. (1991). "Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells". J. Clin. Invest. 87 (4): 1139–45. doi:10.1172/JCI115110. PMC 295116. PMID 2010530. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=295116.
- Kroschwald P, Kroschwald A, Kühn H et al. (1989). "Occurrence of the erythroid cell specific arachidonate 15-lipoxygenase in human reticulocytes". Biochem. Biophys. Res. Commun. 160 (2): 954–60. doi:10.1016/0006-291X(89)92528-X. PMID 2719708.
- Sigal E, Nadel JA (1989). "Arachidonic acid 15-lipoxygenase and airway epithelium. Biologic effects and enzyme purification". Am. Rev. Respir. Dis. 138 (6 Pt 2): S35–40. PMID 3202520.
- Sigal E, Craik CS, Highland E et al. (1989). "Molecular cloning and primary structure of human 15-lipoxygenase". Biochem. Biophys. Res. Commun. 157 (2): 457–64. doi:10.1016/S0006-291X(88)80271-7. PMID 3202857.
- Sigal E, Grunberger D, Craik CS et al. (1988). "Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases". J. Biol. Chem. 263 (11): 5328–32. PMID 3356688.
- Nassar GM, Morrow JD, Roberts LJ et al. (1994). "Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes". J. Biol. Chem. 269 (44): 27631–4. PMID 7961680.
- Kritzik MR, Ziober AF, Dicharry S et al. (1997). "Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene". Biochim. Biophys. Acta 1352 (3): 267–81. PMID 9224951.
- Brinckmann R, Schnurr K, Heydeck D et al. (1998). "Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme". Blood 91 (1): 64–74. PMID 9414270.
- Kelavkar U, Wang S, Montero A et al. (1998). "Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes". Mol. Biol. Rep. 25 (3): 173–82. doi:10.1023/A:1006813009006. PMID 9700053.
- Roy B, Cathcart MK (1998). "Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes". J. Biol. Chem. 273 (48): 32023–9. doi:10.1074/jbc.273.48.32023. PMID 9822675.
- Kratky D, Lass A, Abuja PM et al. (1999). "A sensitive chemiluminescence method to measure the lipoxygenase catalyzed oxygenation of complex substrates". Biochim. Biophys. Acta 1437 (1): 13–22. PMID 9931410.
- Kelavkar UP, Badr KF (1999). "Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: Evidence that 15-lipoxygenase is a mutator gene". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4378–83. doi:10.1073/pnas.96.8.4378. PMC 16340. PMID 10200270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16340.
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| 1.13.11: two atoms of oxygen |
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| 1.13.12: one atom of oxygen |
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| 1.13.99: other |
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B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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