ALG3

Asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)
Identifiers
Symbols ALG3; CDG1D; CDGS4; D16Ertd36e; NOT56L; Not56
External IDs OMIM: 608750 MGI: 1098592 HomoloGene: 4228 GeneCards: ALG3 Gene
EC number 2.4.1.130
Orthologs
Species Human Mouse
Entrez 10195 208624
Ensembl ENSG00000214160 ENSMUSG00000033809
UniProt Q92685 Q8K2A8
RefSeq (mRNA) NM_001006941.2 NM_145939.2
RefSeq (protein) NP_001006942.1 NP_666051.2
Location (UCSC) Chr 3:
183.96 – 183.97 Mb		 Chr 16:
20.61 – 20.61 Mb
PubMed search [1] [2]

Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an enzyme that in humans is encoded by the ALG3 gene.[1][2]

This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation.[2]

References

  1. ^ Jerrold LE (Dec 1975). "Will an electric current replace the syringe for anesthesia?". Dent Stud 53 (5): 49, 54. PMID 1058125. 
  2. ^ a b "Entrez Gene: ALG3 asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10195. 

Further reading

External links

2.4.1: Hexosyl-
transferases
POFUT1 · POFUT2 · FUT1 · FUT2 · FUT3 · FUT4 · FUT5 · FUT6 · FUT7 · FUT8 · FUT9 · FUT10 · FUT11
2.4.2: Pentosyl-
transferases
Other
Other
2.4.99: Sialyl
transferases
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6