Aldehyde dehydrogenase 9 family, member A1

Aldehyde dehydrogenase 9 family, member A1
Identifiers
Symbols ALDH9A1; ALDH4; ALDH7; ALDH9; E3; TMABADH
External IDs OMIM: 602733 MGI: 1861622 HomoloGene: 55483 GeneCards: ALDH9A1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 223 56752
Ensembl ENSG00000143149 ENSMUSG00000026687
UniProt P49189 Q3TG52
RefSeq (mRNA) NM_000696 NM_019993.3
RefSeq (protein) NP_000687 NP_064377.2
Location (UCSC) Chr 1:
165.63 – 165.67 Mb		 Chr 1:
169.28 – 169.3 Mb
PubMed search [1] [2]

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[1][2][3]

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[3]

References

  1. ^ McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (Mar 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Hum Genet 93 (2): 211–2. PMID 8112751. 
  2. ^ Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (Sep 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138. 
  3. ^ a b "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=223. 

Further reading

  • Kurys G, Ambroziak W, Pietruszko R (1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde.". J. Biol. Chem. 264 (8): 4715–21. PMID 2925663. 
  • Kurys G, Shah PC, Kikonygo A, et al. (1994). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde.". Eur. J. Biochem. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919. 
  • Kikonyogo A, Pietruszko R (1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution.". Biochem. J. 316 ( Pt 1): 317–24. PMID 8645224. 
  • Izaguirre G, Kikonyogo A, Pietruszko R (1998). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution.". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 118 (1): 59–64. PMID 9417993. 
  • Vaz FM, Fouchier SW, Ofman R, et al. (2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.". J. Biol. Chem. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312. 
  • Izaguirre G, Pietruszko R, Cho S, MacKerell A (2002). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs.". J. Biomol. Struct. Dyn. 19 (3): 429–47. PMID 11790142. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.