ALDH1L2

Aldehyde dehydrogenase 1 family, member L2

Identifiers

ALDH1L2; DKFZp686A16126; DKFZp686M064; DKFZp686P14145; FLJ36769; FLJ38508; MGC119536; MGC119537; mtFDH

External IDs

OMIM: 613584 MGI: 2444680 HomoloGene: 51942 GeneCards: ALDH1L2 Gene

1.5.1.6

Gene Ontology
Molecular function	• acyl carrier activity • methyltransferase activity • formyltetrahydrofolate dehydrogenase activity • oxidoreductase activity • hydroxymethyl-, formyl- and related transferase activity • phosphopantetheine binding • cofactor binding
Cellular component	• cytoplasm • mitochondrion
Biological process	• biosynthetic process • 10-formyltetrahydrofolate catabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
105.41 – 105.48 Mb

Chr 10:
82.95 – 83 Mb

PubMed search

[1]

[2]

Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene.^[1]^[2] ALDH1L2 is an aldehyde dehydrogenase.

References

^ Strausberg RL, Feingold EA, Grouse LH, et al (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
^ Ota T, Suzuki Y, Nishikawa T, et al (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Strickland KC, Hoeferlin LA, Oleinik NV, et al. (2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2804320.

Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP	Aldehyde dehydrogenase: Acetaldehyde dehydrogenase (ALDH2) · Long-chain-aldehyde dehydrogenase Glyceraldehyde 3-phosphate dehydrogenase

1.2.2: cytochrome	Formate dehydrogenase (cytochrome)

1.2.3: oxygen	Aldehyde oxidase

1.2.4: disulfide	Oxoglutarate dehydrogenase · Pyruvate dehydrogenase · Branched-chain alpha-keto acid dehydrogenase complex (BCKDHA, BCKDHB, DBT, DLD)

1.2.7: iron-sulfur protein	Pyruvate synthase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

ALDH1L2

References

Further reading