ALDH1L1

Aldehyde dehydrogenase 1 family, member L1

PDB rendering based on 1s3i.
Identifiers
Symbols ALDH1L1; 10-fTHF; DKFZp781N0997; FDH; FTHFD
External IDs OMIM600249 MGI1340024 HomoloGene122031 GeneCards: ALDH1L1 Gene
EC number 1.5.1.6
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10840 107747
Ensembl ENSG00000144908 ENSMUSG00000030088
UniProt O75891 Q8BLE0
RefSeq (mRNA) NM_012190 NM_027406.1
RefSeq (protein) NP_036322 NP_081682.1
Location (UCSC) Chr 3:
125.82 – 125.92 Mb
Chr 6:
90.52 – 90.56 Mb
PubMed search [1] [2]

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.[1]

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.[1]

References

Further reading