AKAP8L

A kinase (PRKA) anchor protein 8-like

Identifiers

AKAP8L; DKFZp434L0650; HA95; HAP95; NAKAP; NAKAP95

External IDs

OMIM: 609475 MGI: 1860606 HomoloGene: 8658 GeneCards: AKAP8L Gene

Gene Ontology
Molecular function	• DNA binding • protein binding • zinc ion binding • DEAD/H-box RNA helicase binding • metal ion binding
Cellular component	• intracellular • nucleus • cytoplasm • nuclear matrix
Biological process	• biological_process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
15.49 – 15.53 Mb

Chr 17:
32.46 – 32.49 Mb

PubMed search

[1]

[2]

A-kinase anchor protein 8-like is an enzyme that in humans is encoded by the AKAP8L gene.^[1]^[2]^[3]

Interactions

AKAP8L has been shown to interact with Thymopoietin^[4]^[5] and DHX9.^[1]^[6]

References

^ ^a ^b Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". J Biol Chem 275 (28): 21396–21401. doi:10.1074/jbc.M909887199. PMID 10748171.
^ Orstavik S, Eide T, Collas P, Han IO, Tasken K, Kieff E, Jahnsen T, Skalhegg BS (Jul 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biol Cell 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID 10761695.
^ "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26993.
^ Martins, S B; Eide T, Steen R L, Jahnsen T, Skålhegg B S, Collas P (Nov. 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". J. Cell. Sci. (ENGLAND) 113 Pt 21: 3703–13. ISSN 0021-9533. PMID 11034899.
^ Martins, Sandra; Eikvar Sissel, Furukawa Kazuhiro, Collas Philippe (Jan. 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". J. Cell Biol. (United States) 160 (2): 177–188. doi:10.1083/jcb.200210026. ISSN 0021-9525. PMC 2172640. PMID 12538639. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172640.
^ Yang, J P; Tang H, Reddy T R, Wong-Staal F (Aug. 2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". J. Biol. Chem. (United States) 276 (33): 30694–30700. doi:10.1074/jbc.M102809200. ISSN 0021-9258. PMID 11402034.

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Seki N, Ueki N, Yano K et al. (2000). "cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region". J. Hum. Genet. 45 (1): 0031–0037. doi:10.1007/s100380070040. PMID 10697960.
Martins SB, Eide T, Steen RL et al. (2001). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". J. Cell. Sci. 113 Pt 21: 3703–13. PMID 11034899.
Yang JP, Tang H, Reddy TR, Wong-Staal F (2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses". J. Biol. Chem. 276 (33): 30694–30700. doi:10.1074/jbc.M102809200. PMID 11402034.
Wistow G, Bernstein SL, Ray S et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Martins S, Eikvar S, Furukawa K, Collas P (2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". J. Cell Biol. 160 (2): 177–188. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172640.
Martins SB, Marstad A, Collas P (2003). "In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling". Biochemistry 42 (35): 10456–10461. doi:10.1021/bi0350699. PMID 12950172.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
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Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
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Sayer JA, Manczak M, Akileswaran L et al. (2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis". Neuromolecular Med. 7 (4): 297–310. doi:10.1385/NMM:7:4:297. PMID 16391387.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

AKAP8L

Interactions

References

Further reading