AKAP8
A-kinase anchor protein 8 is an enzyme that in humans is encoded by the AKAP8 gene.[1][2]
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.[2]
Interactions
AKAP8 has been shown to interact with DDX5,[3] AMY1A,[4] MCM2,[5] Cyclin D3[6] and PRKAR2A.[1][7]
References
- ^ a b Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res 238 (2): 305–16. doi:10.1006/excr.1997.3855. PMID 9473338.
- ^ a b "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10270.
- ^ Akileswaran, L; Taraska J W, Sayer J A, Gettemy J M, Coghlan V M (May. 2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. (United States) 276 (20): 17448–54. doi:10.1074/jbc.M101171200. ISSN 0021-9258. PMID 11279182.
- ^ Furusawa, Makoto; Taira Takahiro, Iguchi-Ariga Sanae M M, Ariga Hiroyoshi (Dec. 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. (United States) 277 (52): 50885–92. doi:10.1074/jbc.M206387200. ISSN 0021-9258. PMID 12414807.
- ^ Eide, Turid; Taskén Kristin A, Carlson Cathrine, Williams Gareth, Jahnsen Tore, Taskén Kjetil, Collas Philippe (Jul. 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. (United States) 278 (29): 26750–6. doi:10.1074/jbc.M300765200. ISSN 0021-9258. PMID 12740381.
- ^ Arsenijevic, Tatjana; Degraef Chantal, Dumont Jacques E, Roger Pierre P, Pirson Isabelle (Mar. 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. (England) 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223988.
- ^ Collas, P; Le Guellec K, Taskén K (Dec. 1999). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. (UNITED STATES) 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. ISSN 0021-9525. PMC 2168084. PMID 10601332. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168084.
Further reading
- Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases.". Recent Prog. Horm. Res. 52: 409–29; discussion 429–30. PMID 9238861.
- Michel JJ, Scott JD (2002). "AKAP mediated signal transduction.". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
- Collas P, Le Guellec K, Taskén K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis.". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC 2168084. PMID 10601332. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168084.
- Steen RL, Cubizolles F, Le Guellec K, Collas P (2000). "A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract.". J. Cell Biol. 149 (3): 531–6. doi:10.1083/jcb.149.3.531. PMC 2174845. PMID 10791967. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174845.
- Akileswaran L, Taraska JW, Sayer JA, et al. (2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase.". J. Biol. Chem. 276 (20): 17448–54. doi:10.1074/jbc.M101171200. PMID 11279182.
- Eide T, Carlson C, Taskén KA, et al. (2002). "Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting.". EMBO Rep. 3 (5): 426–32. doi:10.1093/embo-reports/kvf089. PMC 1084102. PMID 11964380. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084102.
- Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Eide T, Taskén KA, Carlson C, et al. (2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication.". J. Biol. Chem. 278 (29): 26750–6. doi:10.1074/jbc.M300765200. PMID 12740381.
- Arsenijevic T, Degraef C, Dumont JE, et al. (2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95.". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223988.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Kamada S, Kikkawa U, Tsujimoto Y, Hunter T (2005). "A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.". Mol. Cell. Biol. 25 (21): 9469–77. doi:10.1128/MCB.25.21.9469-9477.2005. PMC 1265837. PMID 16227597. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1265837.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.