ACER2

Alkaline ceramidase 2

Identifiers

ACER2; ALKCDase2; ASAH3L; FLJ41587

External IDs

OMIM: 613492 MGI: 1920932 HomoloGene: 14986 GeneCards: ACER2 Gene

3.5.1.23

Gene Ontology
Molecular function	• hydrolase activity • ceramidase activity • ceramidase activity
Cellular component	• Golgi membrane • Golgi apparatus • membrane • integral to membrane • integral to Golgi membrane
Biological process	• negative regulation of cell-matrix adhesion • lipid metabolic process • sphingolipid metabolic process • ceramide metabolic process • positive regulation of cell proliferation • response to retinoic acid • negative regulation of cell adhesion mediated by integrin • sphingosine biosynthetic process • negative regulation of protein glycosylation in Golgi
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
19.41 – 19.45 Mb

Chr 4:
86.52 – 86.58 Mb

PubMed search

[1]

[2]

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.^[1]

Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.^[2]

References

^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2614331.
^ Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785. PMID 18945876. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2630785.

Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153.
.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.

Metabolism: lipid metabolism · glycolipid enzymes

Sphingolipid

To glycosphingolipid	Glycosyltransferase · Sulfotransferase

To ceramide	From ganglioside: Beta-galactosidase · Hexosaminidase A · Neuraminidase · Glucocerebrosidase From globoside: Hexosaminidase B · Alpha-galactosidase · Beta-galactosidase · Glucocerebrosidase From sphingomyelin: Sphingomyelin phosphodiesterase (Sphingomyelin phosphodiesterase 1) From sulfatide: Arylsulfatase A · Galactosylceramidase

To sphingosine	Ceramidase (ACER1, ACER2, ACER3, ASAH1, ASAH2, ASAH2B, ASAH2C)

Other	Sphingosine kinase

NCL

Palmitoyl protein thioesterase · Tripeptidyl peptidase I · CLN3 · CLN5 · CLN6 · CLN8

Ceramide synthesis

Serine C-palmitoyltransferase (SPTLC1) · Ceramide glucosyltransferase (UGCG)

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

ACER2

Function

References

Further reading