ACCN1

Amiloride-sensitive cation channel 1, neuronal

Identifiers

ACCN1; ACCN; ASIC2; ASIC2a; BNC1; BNaC1; MDEG; hBNaC1

External IDs

OMIM: 601784 MGI: 1100867 HomoloGene: 90965 GeneCards: ACCN1 Gene

Gene Ontology
Molecular function	• ion channel activity • protein binding • ligand-gated sodium channel activity
Cellular component	• plasma membrane • integral to plasma membrane
Biological process	• ion transport • synaptic transmission • central nervous system development • peripheral nervous system development • monovalent inorganic cation transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
31.34 – 32.48 Mb

Chr 11:
80.7 – 81.78 Mb

PubMed search

[1]

[2]

Amiloride-sensitive cation channel 1, neuronal is a protein that in humans is encoded by the ACCN1 gene.^[1]^[2]

1 Function
2 See also
3 References
4 Further reading

Function

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.^[2]

References

^ Waldmann R, Voilley N, Mattei MG, Lazdunski M (Feb 1997). "The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798". Genomics 37 (2): 269–70. doi:10.1006/geno.1996.0558. PMID 8921408.
^ ^a ^b "Entrez Gene: ACCN1 amiloride-sensitive cation channel 1, neuronal (degenerin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=40.

Price MP, Snyder PM, Welsh MJ (1996). "Cloning and expression of a novel human brain Na+ channel.". J. Biol. Chem. 271 (14): 7879–82. doi:10.1074/jbc.271.14.7879. PMID 8626462.
Waldmann R, Champigny G, Voilley N et al. (1996). "The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans". J. Biol. Chem. 271 (18): 10433–6. doi:10.1074/jbc.271.18.10433. PMID 8631835.
García-Añoveros J, Derfler B, Neville-Golden J et al. (1997). "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1459–64. doi:10.1073/pnas.94.4.1459. PMC 19813. PMID 9037075. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19813.
Bassilana F, Champigny G, Waldmann R et al. (1997). "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties". J. Biol. Chem. 272 (46): 28819–22. doi:10.1074/jbc.272.46.28819. PMID 9360943.
Babinski K, Catarsi S, Biagini G, Séguéla P (2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". J. Biol. Chem. 275 (37): 28519–25. doi:10.1074/jbc.M004114200. PMID 10842183.
Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374.
Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222326.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Price MP, Thompson RJ, Eshcol JO et al. (2005). "Stomatin modulates gating of acid-sensing ion channels". J. Biol. Chem. 279 (51): 53886–91. doi:10.1074/jbc.M407708200. PMID 15471860.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Saugstad JA, Roberts JA, Dong J et al. (2005). "Analysis of the Membrane Topology of the Acid-sensing Ion Channel 2a". J. Biol. Chem. 279 (53): 55514–9. doi:10.1074/jbc.M411849200. PMC 2928846. PMID 15504740. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2928846.
Vila-Carriles WH, Kovacs GG, Jovov B et al. (2006). "Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells". J. Biol. Chem. 281 (28): 19220–32. doi:10.1074/jbc.M603100200. PMID 16704974.
Chai S, Li M, Lan J et al. (2007). "A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a". J. Biol. Chem. 282 (31): 22668–77. doi:10.1074/jbc.M703624200. PMID 17548344.
Joch M, Ase AR, Chen CX et al. (2007). "Parkin-mediated Monoubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels". Mol. Biol. Cell 18 (8): 3105–18. doi:10.1091/mbc.E05-11-1027. PMC 1949385. PMID 17553932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1949385.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Voltage-gated	L-type/Ca_vα (1.1, 1.2, 1.3, 1.4) · N-type/Ca_vα2.2 · P-type/Ca_vα(2.1) · Q-type/Ca_vα2.1 · R-type/Ca_vα2.3 · T-type/Ca_vα(3.1, 3.2, 3.3) α₂δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4) Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)

Ligand-gated	Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel (α, β, γ, δ)

Proton gated	Amiloride-sensitive cation channel (1, 2, 3, 4)

Voltage-gated	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Na_vβ (1, 2, 3, 4)

K⁺: Potassium channel

Voltage-gated	K_vα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) K_vα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) K_vβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene

Calcium-activated	BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · K_Ca (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)

Inward-rectifier	K_ATP · K_ir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) · GIRK/K_ir (3.1, 3.2, 3.3, 3.4) · K_ir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)

Tandem pore domain	K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other

Cl^-: Chloride channel	ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)

H⁺: Voltage-gated	HVCN1

M⁺: TRP cation channel	TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPN · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)

Cyclic nucleotide-gated (FC)	α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family

Gap junction	Connexin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) · B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) · C (GJC1, GJC2, GJC3) · D (GJD2, GJD3, GJD4)) Innexin

General	Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

ACCN1

Contents

Function

See also

References

Further reading