ACAT2

acetyl-Coenzyme A acetyltransferase 2

PDB rendering based on 1wl4.
Identifiers
Symbol ACAT2
External IDs OMIM100678 MGI109182 HomoloGene55855 GeneCards: ACAT2 Gene
EC number 2.3.1.9
Orthologs
Species Human Mouse
Entrez 39 224530
Ensembl ENSG00000120437 ENSMUSG00000062480
UniProt Q9BWD1 Q80X81
RefSeq (mRNA) NM_005891 NM_009338
RefSeq (protein) NP_005882 NP_694791
Location (UCSC) Chr 6:
160.1 – 160.12 Mb
Chr 17:
13.12 – 13.13 Mb
PubMed search [1] [2]

Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene[1][2] that is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB.

Acetyl-Coenzyme A acetyltransferase 2 is an acetyl-CoA C-acetyltransferase enzyme.

Contents

Gene

This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.[1]

Function

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase.[1]

In a study done on rats, it was found that rats fed a fat-enriched diet whose ACAT2 gene were deleted were protected from dietary fat-induced atherosclerosis. LDL concentration, CE composition, and particle size were affected in ways that reduced atherogenesis in comparison to other rats whose ACAT2 gene were not modified.[3]

References


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.