ABCC1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

PDB rendering based on 2cbz.
Identifiers
Symbols ABCC1; ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; MRP; MRP1
External IDs OMIM: 158343 MGI: 102676 HomoloGene: 55459 GeneCards: ABCC1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4363 17250
Ensembl ENSG00000103222 ENSMUSG00000023088
UniProt P33527 Q3UDM1
RefSeq (mRNA) NM_004996.3 NM_008576.2
RefSeq (protein) NP_004987.2 NP_032602.1
Location (UCSC) Chr 16:
16.04 – 16.24 Mb		 Chr 16:
14.36 – 14.48 Mb
PubMed search [1] [2]

Multidrug resistance-associated protein 1 is a protein that in humans is encoded by the ABCC1 gene.[1][2]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.[3]

ABCC1 clears beta-amyloid from brains of mice and can be activated by thiethylperazine. [4]

Contents

See also

References

  1. ^ Cole SP, Deeley RG (Jun 1993). "Multidrug resistance-associated protein: sequence correction". Science 260 (5110): 879. doi:10.1126/science.8098549. PMID 8098549. 
  2. ^ Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (Jan 1993). "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line". Science 258 (5088): 1650–4. doi:10.1126/science.1360704. PMID 1360704. 
  3. ^ "Entrez Gene: ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4363. 
  4. ^ Science Daily (September 1, 2011). "Alzheimer Disease: Transport Protein ABCC1 Plays Key Role in Clearing Beta-Amyloid from Brains of Mice.". http://www.sciencedaily.com/releases/2011/09/110901134628.htm. Retrieved September 1, 2011. 

Further reading

  • Lautier D, Canitrot Y, Deeley RG, Cole SP (1996). "Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.". Biochem. Pharmacol. 52 (7): 967–77. doi:10.1016/0006-2952(96)00450-9. PMID 8831715. 
  • Deeley RG, Cole SP (1998). "Function, evolution and structure of multidrug resistance protein (MRP).". Semin. Cancer Biol. 8 (3): 193–204. doi:10.1006/scbi.1997.0070. PMID 9441948. 
  • Hegedus T, Orfi L, Seprodi A, et al. (2002). "Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.". Biochim. Biophys. Acta 1587 (2–3): 318–25. PMID 12084474. 
  • Chang XB (2007). "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1". Cancer Metastasis Rev. 26 (1): 15–37. doi:10.1007/s10555-007-9041-7. PMID 17295059. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

A
A1 · A2 · A3 · A4 · A7 · A8 · A12 · A13
B
B1 · B2-3 (B2, B3) · B4 · B5 · B6 · B7 · B9 · B11
C
C1 · C2 · C3 · C4 · C5 · C6 · C7 · C8-9 (C8, C9) · C10 · C11 · C13
D
D1 · D2 · D3 · D4
E
F
F1 · F2
G
G1 · G2 · G4 · Sterolin (G5, G8)
see also ABC transporter disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr