ABCB8

ATP-binding cassette, sub-family B (MDR/TAP), member 8
Identifiers
Symbols ABCB8; EST328128; M-ABC1; MABC1
External IDs OMIM: 605464 MGI: 1351667 HomoloGene: 5203 GeneCards: ABCB8 Gene
Orthologs
Species Human Mouse
Entrez 11194 74610
Ensembl ENSG00000197150 ENSMUSG00000028973
UniProt Q9NUT2 n/a
RefSeq (mRNA) NM_007188 NM_029020.2
RefSeq (protein) NP_009119 NP_083296.2
Location (UCSC) Chr 7:
150.73 – 150.74 Mb		 Chr 5:
23.9 – 23.92 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.[1][2]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.[2]

See also

References

  1. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702. 
  2. ^ a b "Entrez Gene: ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11194. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.