| A-77636 | |
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(1R,3S)-3-(1-Adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol[1] |
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| Identifiers | |
| CAS number | 778546-51-3 , 145307-34-2 (HCl) |
| PubChem | 6603703, 9951033 (HCl) |
| ChemSpider | 5036017 |
| ChEMBL | CHEMBL313530 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C20H27NO3 |
| Molar mass | 329.43 g mol−1 |
| Exact mass | 329.199093735 g mol-1 |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
A-77636 is a synthetic drug which acts as a selective D1 receptor full agonist.[2] It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies,[3][4][5][6][7] but its high potency and long duration of action causes D1 receptor downregulation and tachyphylaxis,[8][9][10] and unlike other D1 full agonists such as SKF-82,958, it does not produce place preference in animals.[11] A-77636 partially substituted for cocaine in animal studies, and has been suggested for use as a possible substitute drug in treating addiction,[12] but it is better known for its use in studying the role of D1 receptors in the brain.[13][14][15]
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