TP53BP1

Tumor protein p53 binding protein 1

PDB rendering based on 1gzh.
Identifiers
Symbols TP53BP1; 53BP1; FLJ41424; MGC138366; p202
External IDs OMIM: 605230 MGI: 1351320 HomoloGene: 4137 GeneCards: TP53BP1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7158 27223
Ensembl ENSG00000067369 ENSMUSG00000043909
UniProt Q12888 Q3UG49
RefSeq (mRNA) NM_001141979.1 NM_013735
RefSeq (protein) NP_001135451.1 NP_038763.3
Location (UCSC) Chr 15:
43.7 – 43.8 Mb		 Chr 2:
121.02 – 121.1 Mb
PubMed search [1] [2]

Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.[1][2][3]

Contents

Clinical significance

53BP1 is underexpressed in most cases of triple-negative breast cancer.[4]

Interactions

TP53BP1 has been shown to interact with Replication protein A1,[5] RPA2,[5] E2F1,[6] Ataxia telangiectasia mutated,[7][8] P53,[9][10][11][12][13][14][1] PAXIP1,[15][16] DYNLL1,[12] H2AFX[10][7][8] and Bloom syndrome protein.[10]

References

  1. ^ a b Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S (Jul 1994). "Two cellular proteins that bind to wild-type but not mutant p53". Proc Natl Acad Sci U S A 91 (13): 6098–102. doi:10.1073/pnas.91.13.6098. PMC 44145. PMID 8016121. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44145. 
  2. ^ Iwabuchi K, Li B, Massa HF, Trask BJ, Date T, Fields S (Nov 1998). "Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2". J Biol Chem 273 (40): 26061–8. doi:10.1074/jbc.273.40.26061. PMID 9748285. 
  3. ^ "Entrez Gene: TP53BP1 tumor protein p53 binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=7158&rn=1. 
  4. ^ Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J (June 2010). "53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers". Nat. Struct. Mol. Biol. 17 (6): 688–95. doi:10.1038/nsmb.1831. PMC 2912507. PMID 20453858. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2912507. 
  5. ^ a b Yoo, Eunjae; Kim Byung U, Lee Seung Youn, Cho Chae Hyun, Chung Jay H, Lee Chang-Hun (Aug. 2005). "53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage". Oncogene (England) 24 (35): 5423–30. doi:10.1038/sj.onc.1208710. ISSN 0950-9232. PMID 15856006. 
  6. ^ Choubey, D; Li S J, Datta B, Gutterman J U, Lengyel P (Oct. 1996). "Inhibition of E2F-mediated transcription by p202". EMBO J. (ENGLAND) 15 (20): 5668–78. ISSN 0261-4189. PMC 452311. PMID 8896460. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452311. 
  7. ^ a b Fernandez-Capetillo, Oscar; Chen Hua-Tang, Celeste Arkady, Ward Irene, Romanienko Peter J, Morales Julio C, Naka Kazuhito, Xia Zhenfang, Camerini-Otero R Daniel, Motoyama Noboru, Carpenter Phillip B, Bonner William M, Chen Junjie, Nussenzweig André (Dec. 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nat. Cell Biol. (England) 4 (12): 993–7. doi:10.1038/ncb884. ISSN 1465-7392. PMID 12447390. 
  8. ^ a b Ward, Irene M; Minn Kay, Jorda Katherine G, Chen Junjie (May. 2003). "Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX". J. Biol. Chem. (United States) 278 (22): 19579–82. doi:10.1074/jbc.C300117200. ISSN 0021-9258. PMID 12697768. 
  9. ^ Derbyshire, Dean J; Basu Balaku P, Serpell Louise C, Joo Woo S, Date Takayasu, Iwabuchi Kuniyoshi, Doherty Aidan J (Jul. 2002). "Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor". EMBO J. (England) 21 (14): 3863–72. doi:10.1093/emboj/cdf383. ISSN 0261-4189. PMC 126127. PMID 12110597. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126127. 
  10. ^ a b c Sengupta, Sagar; Robles Ana I, Linke Steven P, Sinogeeva Natasha I, Zhang Ran, Pedeux Remy, Ward Irene M, Celeste Arkady, Nussenzweig André, Chen Junjie, Halazonetis Thanos D, Harris Curtis C (Sep. 2004). "Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest". J. Cell Biol. (United States) 166 (6): 801–13. doi:10.1083/jcb.200405128. ISSN 0021-9525. PMC 2172115. PMID 15364958. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172115. 
  11. ^ Ekblad, Caroline M S; Friedler Assaf, Veprintsev Dmitry, Weinberg Richard L, Itzhaki Laura S (Mar. 2004). "Comparison of BRCT domains of BRCA1 and 53BP1: A biophysical analysis". Protein Sci. (United States) 13 (3): 617–25. doi:10.1110/ps.03461404. ISSN 0961-8368. PMC 2286730. PMID 14978302. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286730. 
  12. ^ a b Lo, Kevin W-H; Kan Ho-Man, Chan Ling-Nga, Xu Wei-Guang, Wang Ke-Peng, Wu Zhenguo, Sheng Morgan, Zhang Mingjie (Mar. 2005). "The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation". J. Biol. Chem. (United States) 280 (9): 8172–9. doi:10.1074/jbc.M411408200. ISSN 0021-9258. PMID 15611139. 
  13. ^ Joo, Woo S; Jeffrey Philip D, Cantor Sharon B, Finnin Michael S, Livingston David M, Pavletich Nikola P (Mar. 2002). "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes Dev. (United States) 16 (5): 583–93. doi:10.1101/gad.959202. ISSN 0890-9369. PMC 155350. PMID 11877378. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155350. 
  14. ^ Derbyshire, Dean J; Basu Balaku P, Date Takayasu, Iwabuchi Kuniyoshi, Doherty Aidan J (Oct. 2002). "Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor". Acta Crystallogr. D Biol. Crystallogr. (Denmark) 58 (Pt 10 Pt 2): 1826–9. doi:10.1107/S0907444902010910. ISSN 0907-4449. PMID 12351827. 
  15. ^ Jowsey, Paul A; Doherty Aidan J, Rouse John (Dec. 2004). "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation". J. Biol. Chem. (United States) 279 (53): 55562–9. doi:10.1074/jbc.M411021200. ISSN 0021-9258. PMID 15456759. 
  16. ^ Manke, Isaac A; Lowery Drew M, Nguyen Anhco, Yaffe Michael B (Oct. 2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting". Science (United States) 302 (5645): 636–9. doi:10.1126/science.1088877. PMID 14576432. 

Further reading