4-Dimethylaminophenol

Not to be confused with 4-Dimethylaminopyridine.
4-Dimethylaminophenol
Identifiers
CAS number 619-60-3 Y
PubChem 22174
ChemSpider 20816 Y
UNII X387L5559O Y
ATC code V03AB27
Jmol-3D images Image 1
Properties
Molecular formula C8H11NO
Molar mass 137.179 g/mol
Boiling point

165 °C (0.040 bar)
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.

Uses

4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1]

It works by generating methemoglobin. [2]

This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.

In an animal model, it has shown effectiveness when given intramuscularly.[3]

See also

References

  1. ^ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91. doi:10.1046/j.1365-2044.2000.01628.x. PMID 11121929. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0003-2409&date=2000&volume=55&issue=12&spage=1189. 
  2. ^ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16. doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V. PMID 8956097. 
  3. ^ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9. PMID 1922842. 
Nervous system
Cardiovascular
Other
Paracetamol toxicity (Acetaminophen)
nitrite (Amyl nitrite, Sodium nitrite#) • Sodium thiosulfate# • 4-Dimethylaminophenol • Hydroxocobalamin
Other
Emetic

M: TOX

gen / txn

pto

ant