3-Methoxymorphinan

3-Methoxymorphinan


Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	1531-25-5^N
ATC code	?
PubChem	CID 5484286
ChemSpider	10207434^Y
Chemical data
Formula	C₁₇H₂₃NO
Mol. mass	257.37 g/mol
InChI InChI=1S/C17H23NO/c1-19-13-6-5-12-10-16-14-4-2-3-7-17(14,8-9-18-16)15(12)11-13/h5-6,11,14,16,18H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1^Y Key:ILNSWVUXAPSPEH-USXIJHARSA-N^Y
N(what is this?) (verify)

3-Methoxymorphinan is a dextromethorphan metabolite that has been shown to produce local anesthetic effects.^[1] It is metabolized in the liver by the enzyme CYP3A4.^[2]

References

^ Hou, Chia-Hui; Tzeng, Jann-Inn (2006). "Dextromethorphan, 3methoxymorphinan, and dextrophan have local anesthetic effect on sciatic nerve blockade in rats". European journal of Pharmacology (Chi-Mei Medical Center, Tainan, Taiwan) 544 (1-3): 10–16. doi:10.1016/j.ejphar.2006.06.013. PMID 16844109. http://www.sciencedirect.com/science/article/pii/S0014299906006285. Retrieved July 2011.
^ Min, Dl; Ku, YM (1999). "A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers". Pharmacotherapy (University of Iowa) 19 (6): 753–759. PMID 10391422. http://www.ncbi.nlm.nih.gov/pubmed/10391422. Retrieved July 2011.