| 24,25-Dihydroxycholecalciferol | |
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(6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol |
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Other names
24,25-dihydroxyvitamin D3 |
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| Identifiers | |
| CAS number | 40013-87-4 |
| PubChem | 6434253 |
| ChemSpider | 4939193 |
| ChEMBL | CHEMBL47183 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C27H44O3 |
| Molar mass | 416.63 g/mol |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
24,25-Dihydroxycholecalciferol, also known as 24,25-dihydroxyvitamin D3 and (24R)-hydroxycalcidiol (abbreviated as 24(R),25-(OH)2D3),[1] is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro[2] and in vivo.[3]
24,25-dihydroxyvitamin D3 is formed from 25-hydroxyvitamin D3 by the action of P450cc24 (25-hydroxyvitamin D3-24-hydroxylase), which appears to be "a multicatalytic enzyme catalyzing most, if not all, of the reactions in the C-24/C-23 pathway of 25-OH-D3 metabolism."[4] It has been proposed that 24,25-dihydroxyvitamin D3 is a metabolite of 25-hydroxyvitamin D3 which is destined for excretion.[4]
It is not known whether the compound might also have some physiologically significant activity. Some evidence of a possible receptor has been obtained.[5]
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