L-AP4

L-AP4
Systematic (IUPAC) name
(2S)-2-amino-4-phosphonobutanoic acid
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 23052-81-5 Y
ATC code  ?
PubChem CID 179394
IUPHAR ligand 1412
Chemical data
Formula C4H10NO5P 
Mol. mass 183.099 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

L-AP4 is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]

References

  1. ^ Thomsen C (1997). "The L-AP4 receptor". General pharmacology 29 (2): 151–8. PMID 9251893. 
  2. ^ Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (2007). "Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease". Journal of Neuroscience 27 (25): 6701–11. doi:10.1523/JNEUROSCI.0299-07.2007. PMID 17581957. 
  3. ^ MacInnes N, Duty S (2008). "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo". European journal of pharmacology 580 (1–2): 95–9. doi:10.1016/j.ejphar.2007.10.030. PMID 18035348. 
  4. ^ Zhang HM, Chen SR, Pan HL (2009). "Effects of Activation of Group III Metabotropic Glutamate Receptors on Spinal Synaptic Transmission in a Rat Model of Neuropathic Pain". Neuroscience 158 (2): 875–84. doi:10.1016/j.neuroscience.2008.10.042. PMC 2649787. PMID 19017536. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2649787. 
  5. ^ MacIejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, Lehner M, Bidziński A et al. (2009). "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration". Brain research 1282: 20–7. doi:10.1016/j.brainres.2009.05.049. PMID 19481536.