| 2-Hydroxyglutaric aciduria | |
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| Classification and external resources | |
Alpha-Hydroxyglutaric acid |
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| OMIM | 600721 236792 |
| DiseasesDB | 34515 34514 |
2-hydroxyglutaric aciduria is a rare, autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid.
Contents |
2-hydroxyglutaric aciduria is an organic aciduria, and has two distinct stereoisomeric variants:
The L-2 form is more common, severe, and mainly affects the central nervous system. The basal ganglia are affected, and cystic cavitations in the white matter of the brain are common, beginning in infancy. This form is chronic, with early symptoms such as hypotonia, tremors, and epilepsy declining into spongiform leukoencephalopathy, muscular choreodystonia, mental retardation, and psychomotor regression.[1]
It is associated with L2HGDH.[2]
The D2 form is rare, with symptoms including macrocephaly, cardiomyopathy, mental retardation, hypotonia, and cortical blindness.[3]
It can be associated with D2HGDH.
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