2-Aminopurine

2-Aminopurine
IUPAC name

7H-purin-2-amine
Identifiers
CAS number 452-06-2
PubChem 9955
ChemSpider 9561 Y
ChEBI CHEBI:479072 Y
ChEMBL CHEMBL388594 Y
Jmol-3D images Image 1
Properties
Molecular formula C5H5N5
Molar mass 135.13 g mol−1
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

2-Aminopurine, an analog of guanine and adenine, is a fluorescent molecular marker used in nucleic acid research.[1] It most commonly pairs with thymine as an adenine-analogue, but can also pair with cytosine as a guanine-analogue;[2]. For this reason it is sometimes used in the laboratory for mutagenesis.

See also

References

  1. ^ Jean JM, Hall KB (2001). "2-Aminopurine fluorescence quenching and lifetimes: role of base stacking". Proc. Natl. Acad. Sci. U.S.A. 98 (1): 37–41. doi:10.1073/pnas.011442198. PMC 14540. PMID 11120885. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=11120885. 
  2. ^ Sowers LC, Fazakerley GV, Eritja R, Kaplan BE, Goodman MF (1986). "Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR". Proc. Natl. Acad. Sci. U.S.A. 83 (15): 5434–5438. doi:10.1073/pnas.83.15.5434. PMC 386301. PMID 3461441. http://www.pnas.org/content/83/15/5434.